MBV4230 - Eukaryotic transcription factors - structures, function, regulation

Schedule, syllabus and examination date

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Course content

The course focus on current understanding of the structure and function of eukaryotic transcription factors. The aim of the first general part is to give the student an understanding of the main components of the eukaryotic transcription apparatus. Topics covered are:RNA polymerase , mechanisms for transcriptional activation, architectural transcription factors, repressors of transcription, role of chromatin structure in transcription and regulation of the activity of transcription factors (signal transduction and posttranslational modifications). In the second part, specific translational factors are discussed: homeodomain and POU families, bZIP- and HLH-families, zinc-finger families, CREB families, the NFkB-family, nuclear receptors, the Myb-family, STAT family, Ets family, p53 and Rb to illustrate the connection between oncogenesis and transcription.

Learning outcome

You will learn to understand central aspects of the complex structure and function of the transcription apparatus which regulates the expression of genes in eucaryotic cells. You should also be able have the basis for understanding resent research the field of eukaryotic transcription.

Admission

Students who are admitted to study programmes at UiO must each semester register which courses and exams they wish to sign up for in Studentweb.

If you are not already enrolled as a student at UiO, please see our information about admission requirements and procedures.

Prerequisites

Recommended previous knowledge

Bachelor degree in molecular biology/biochemistry and/or admission to Master program in molecular bioscience or equivalent background, MBV4010 - Methods in molecular biology and biochemistry I, MBV4020 - Methods in molecular biology and biochemistry II, MBV3040 - Biochemistry of the nucleic acids (discontinued) or corresponding knowledge.

Teaching

20 lectures and 10 student seminars are concentrated over 3 weeks .

Examination

Final three hour written exam appr. two weeks after the end of the course.(Optional oral exam depending on the number of participants.)

 

Examination support material

No examination support material is allowed.

Grading scale

Grades are awarded on a scale from A to F, where A is the best grade and F is a fail. Read more about the grading system.

Explanations and appeals

Resit an examination

This course offers both postponed and resit of examination. Read more:

Withdrawal from an examination

It is possible to take the exam up to 3 times. If you withdraw from the exam after the deadline or during the exam, this will be counted as an examination attempt.

Special examination arrangements

Application form, deadline and requirements for special examination arrangements.

Facts about this course

Credits

10

Level

Master

Teaching

Every autumn

Examination

Every autumn

Teaching language

Norwegian (English on request)