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KJM5250 - Organic NMR Spectroscopy

Course content

Lectures include the following topics: Chemical shifts, coupling constants, relaxation (T1 and T2). Practical aspects for optimization of NMR experiments. Tuning and Matching. Shimming. Selection of acquisition and processing parameters. Information transfer via coupling constants and through space (Overhauser effect). One dimensional and two dimensional pulse sequences. The time dimensions t1 and t2. The frequency dimensions F1 and F2. “Window functions”. Intepretation of spectra. Rational choice of type of experiment, acquisition- and processing-parameters in relation to chemical problem. Vector and spin population models in explanation of NMR phenomena and the individual experiment. Inverse detected experiments. The laboratory course (one day each week for 10 weeks) includes the following NMR experiments which are performed by two or three students together. Pulse angle optimization, selective 1H - 1H decoupling, T1/T2 relaxation time determination, DEPT, NOEDIF, COSY, TOCSY, XHCORR (HETCOR), COLOC, HMBC or HSQC, HMBC, NOESY and ROESY. A new goal from the spring of 2010 is to enhance the competence of setting up new experiments without having a detailed instruction.

Learning outcomes

After completion of KJM 5250

• You will be able to make a rational choice of type of nmr-experiments for the nuclei; 1H, 13C,19F, 31P and 15N and combinations thereof and can choose and implement acquisition- and processing-parameters in relation to chemical problems.
• You will master vector and spin population models in explanation of nmr phenomena.
• You understand the concepts of tuning/matching and master the practical art of shimming.
• You will understand the concepts of T1- and T2-relaxation and you know how to measure them and how to set up and perform experiments to measure them.
• You understand the concepts of information transfer through electrons in bonds as well as through space via the Overhauser effect. You will understand and can explain the mechanism of the Overhauser effect.
• You understand the concepts of one- and two- dimensional pulse sequences as well as the time dimensions t1 and t2 and the frequency dimensions f1 and f2.
• You understand the concepts of and can apply “window functions” and “ linear prediction” in one and two dimensions.
• You understand the differences between inversely and directly detected experiments and know when to choose either of them.
• You will master: pulse angle optimization, selective 1H-1H decoupling, DEPT(45, 90, 135), COSY(GP), TOCSY(GP), XHCORR (HETCOR), COLOC, HSQC(EDETGP), HMBCGP, NOESY and ROESY experiments.
• You are able to interpretate and put together information from a series of nmr experiments in elucidation of chemical structures and problems.

Admission

Students at UiO must apply for courses in StudentWeb.

International applicants, if you are not already enrolled as a student at UiO, please see our information about admission requirements and procedures for international applicants.

Prerequisites

Formal prerequisites

None.

Recommended prior knowledge

KJM3000 - Applied spectroscopy, as well as practical knowledge in acquisition of one dimensional 1H- and 13C-NMR spectra with Bruker Avance instruments using the NMR program TopSpin 1.3. The NMR module in KJM-MENA4010 - Experimental methods (accessible for Master's students, and which normally runs immediately prior to KJM5250) is highly recommended.

Overlap

10 credits against KJM9250 - Organic NMR Spectroscopy.

Teaching

The course includes 20 hours of lectures and a laboratory course of 50 hours. Approved laboratory course is a prerequisite for taking the exam.

Exam information

The exam includes tests of practical skills in the laboratory as well as oral examination of theoretical knowledge. Approved laboratory course is a prerequisite for taking the exam.

Assessment and grading

Course grades are awarded on a descending scale using alphabetic grades from A to E for passes and F for fail. Read more about the grading system .

Explanations and appeals

Students can request an explanation of their grades, and can also appeal against their grades or make a complaint about formal examination errors. Read more about explanations and appeals

Possibility of make-up exams and re-takes

You can usually resit an exam, but the conditions depend on whether you had a valid reason for absence from the regular exam. Read more about resitting an exam .

Withdrawing from exams and limits on re-takes

A student can sit for this exam up to 3 times. If a student wishes to withdraw from the exam, s/he must do this in StudentWeb at least two weeks prior to the first day of the exam. Failure to do so will be counted as one of the three opportunities to sit for the exam.

Exam options for students with special needs

Students may apply for access to alternative exam resources or exam forms on the basis of chronic illness and/or special needs that create a marked disadvantage to other students in the exam situation. Mothers who are breastfeeding may apply for extra time to complete the exam.

Evaluation of this course

Feedback from our students is essential to us in our efforts to ensure and further improve the high quality of our programmes and courses. As a student at the University of Oslo you will therefore be asked to participate in various types of evaluation of our courses, facilities and services. All courses are subject to continuous evaluation. At regular intervals we also ask students on a particular course to participate in a more comprehensive, in-depth evaluation of this course, a so called "periodic evaluation".

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