MF9380 - Population-based Association Analysis
Course content
The course is intended to give an understanding of concepts and methods related to the analysis of SNP/SNV data in population-based studies. It will focus on basic concepts of genetic epidemiology and, population genetics as well as statistical methods and tools needed for this kind of genetic data. The course is based on the PLINK software, a short introduction will be given. We will also have a short look into
methods handling sequencing and methylation data.
Learning outcome
1.Basic concepts of genetic epidemiology: Hardy-Weinberg equilibrium, haplotypes, linkage disequilibrium, tagSNP selection methods, SNP data quality control, study designs, population stratification, Imputation.
2.Introduction in PLINK software.
3.Analysis of Qualitative and Quantitative traits: tests for contingency tables and regression models.
4.Multifactorial Analysis of Genotypes: (logistic) regression, likelihood-ratio test
5.Multiple testing problem
6.Genome-wide Association Studies
7.Analysis of Sequencing Data
8.Summary and Outview
Admission
Ph.D. candidates and students at the Medical Student Research Programm will get first priority to the course. Maximum number of particpants is 30.
Registration in the StudentWeb - 1st December until 1st February.
Registration for applicants without access to the StudentWeb - 1st December until 1st February.
Applicants will be notified by email 1 - 2 weeks after the final date for registration.
Prerequisites
Formal prerequisite knowledge
Basic knowledge of statistics, equivalent to an introductory course.
Recommended previous knowledge
Basic computational skills
Teaching
The course is organized as full day teaching over 4-5 days, including introduction to PLINK as well as lectures and group- exercises in PC-labs.
NB! You have to participate in at least 80 % of the teaching to be allowed to take the exam. Attendance at lectures will be registered.
Examination
A take-home exam will be given at the end of the course. Grading: Pass/fail.
Take-Home-Exam:
The test format consists mainly of multiple choice, short-answer essay questions and short calculations. The Exam will include questions taken from the lectures and readings. You will have 3 weeks to complete after the course.
Explanations and appeals
Students can request an explanation of their grades, and can also appeal against their grades or make a complaint about formal examination errors. Read more about explanations and appeals
Evaluation
Feedback from our students is essential to us in our efforts to ensure and further improve the high quality of our programmes and courses. All courses are subject to continuous evaluation. At regular intervals we also ask students on a particular course to participate in a more comprehensive, periodic evaluation of this course.