Per Morten Sandset

• Bøhn, Siv Kjølsrud; Thune, Inger; Flote, Vidar Gordon; Frydenberg, Hanne; Falkenér Bertheussen, Gro; Husøy, Anders; Fjeldheim, Frøydis Nyborg; Hjellegjerde Brunvoll, Sonja; Hjartåker, Anette; Mowinckel, Marie-Christine; Sandset, Per Morten & Iversen, Per Ole (2021). Effects of a One-Year Physical Activity Intervention on Markers of Hemostasis among Breast Cancer Survivors - A Randomized Controlled Trial. TH Open.  ISSN 2512-9465. Full text in Research Archive.
• Engeseth, Marit; Enden, Tone Rønnaug; Sandset, Per Morten & Wik, Hilde Skuterud (2021). Predictors of long-term post-thrombotic syndrome following high proximal deep vein thrombosis: a cross-sectional study. Thrombosis Journal.  ISSN 1477-9560.  19:3, s 1- 7 . doi: 10.1186/s12959-020-00253-8
• Khialani, Deeksha; Vasan, Sowmya; Cushman, Mary; Dahm, Anders Erik Astrup; Sandset, Per Morten; Rossouw, Jacques & van Hylckama Vlieg, Astrid (2021). Venous thrombosis with oral postmenopausal hormone therapy: Roles of activated protein C resistance and tissue factor pathway inhibitor. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933. . doi: 10.1111/jth.15319
• Andersen, Nina Gjerde; Mowinckel, Marie-Christine; Sunde, Kjetil; Sandset, Per Morten & Beitland, Sigrid (2020). Utility of coagulation analyses to assess thromboprophylaxis with dalteparin in intensive care unit patients. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  s 1- 10 . doi: 10.1111/aas.13748 Full text in Research Archive.
• Andresen, Marianne Seierstad; Stavik, Benedicte; Sletten, Marit; Tinholt, Mari; Sandset, Per Morten; Iversen, Nina & Skretting, Grethe (2020). Indirect regulation of TFPI-2 expression by miR-494 in breast cancer cells. Scientific Reports.  ISSN 2045-2322.  10:4036, s 1- 10 . doi: 10.1038/s41598-020-61018-x Full text in Research Archive.
• Godolphin, Peter J.; Bath, Philip M.; Partlett, Christopher; Berge, Eivind; Brown, Martin M; Eliasziw, Misha; Sandset, Per Morten; Serena, Joaquín & Montgomery, Alan A. (2020). Outcome assessment by central adjudicators in randomised stroke trials: Simulation of differential and non-differential misclassification. European Stroke Journal.  ISSN 2396-9873.  5(2), s 174- 183 . doi: 10.1177/2396987320910047 Full text in Research Archive.
• Hannevik, Trine-Lise; Brekke, Jorunn; Enden, Tone Rønnaug; Frøen, Hege; Ahmed, Herish; Jacobsen, Eva-Marie; Quist-Paulsen, Petter; Porojnicu, Alina Carmen; Ree, Anne Hansen; Torfoss, Dag; Velle, Elin Osvik; Wik, Hilde Skuterud; Ghanima, Waleed Khalid; Sandset, Per Morten & Dahm, Anders Erik A (2020). Thrombosis and bleedings in a cohort of cancer patients treated with apixaban for venous thromboembolism. Thrombosis Research.  ISSN 0049-3848.  196, s 238- 244 . doi: 10.1016/j.thromres.2020.08.042
• Harrison, Sean; Siller, Richard; Tanaka, Yoshiaki; Xiang, Yangfei; Patterson, Benjamin; Kempf, Henning; Melum, Espen; Åsrud, Kathrine Sivertsen; Dugarte, Maria Eugenia Chollet; Andersen, Elisabeth; Sandset, Per Morten; Baumgarten, Saphira Felicitas; Bonanini, Flavio; Kurek, Dorota; Mathapati, Santosh Sadashiv; Almaas, Runar; Sharma, Kulbhushan; Wilson, Steven Ray Haakon; Skottvoll, Frøydis Sved; Boger, Ida Caroline Sneis; Bogen, Inger Lise; Nyman, Tuula Anneli; Wu, Jun J.; Bezrouk, Ales; Cizkova, Dana; Mokrý, Jaroslav; Zweigerdt, Robert; Park, In-Hyun & Sullivan, Gareth (2020). Scalable production of tissue-like vascularised liver organoids from human PSCs.. BioRxiv.  ISSN 0362-4331. . doi: 10.1101/2020.12.02.406835
• Thorsen, Lene; Haugnes, Hege Sagstuen; Fosså, Sophie Dorothea; Brydøy, Marianne; Tandstad, Torgrim; Wisløff, Torbjørn; Gjerset, Gunhild Maria; Edvardsen, Elisabeth; Larsen, Karl-Otto; Sandset, Per Morten; Henriksson, Carola; Raastad, Truls & Negaard, Helene Francisca Stigter (2020). Thromboembolic events after high-intensity training duringcisplatin-based chemotherapy for testicular cancer: Casereports and review of the literature. International Journal of Cancer.  ISSN 0020-7136.  147(11), s 3189- 3198 . doi: 10.1002/ijc.33151 Full text in Research Archive. Show summary

  The randomized “Testicular cancer and Aerobic and Strength Training trial” (TAST‐trial) aimed to evaluate the effect of high‐intensity interval training (HIIT) on cardiorespiratory fitness during cisplatin‐based chemotherapy (CBCT) for testicular cancer (TC). Here, we report on an unexpected high number of thromboembolic (TE) events among patients randomized to the intervention arm, and on a review of the literature on TE events in TC patients undergoing CBCT. Patients aged 18 to 60 years with a diagnosis of metastatic germ cell TC, planned for 3 to 4 CBCT cycles, were randomized to a 9 to 12 weeks exercise intervention, or to a single lifestyle counseling session. The exercise intervention included two weekly HIIT sessions, each with 2 to 4 intervals of 2 to 4 minutes at 85% to 95% of peak heart rate. The study was prematurely discontinued after inclusion of 19 of the planned 94 patients, with nine patients randomized to the intervention arm and 10 to the control arm. Three patients in the intervention arm developed TE complications; two with pulmonary embolism and one with myocardial infarction. All three patients had clinical stage IIA TC. No TE complications were observed among patients in the control arm. Our observations indicate that high‐intensity aerobic training during CBCT might increase the risk of TE events in TC patients, leading to premature closure of the TAST‐trial.

• Tinholt, Mari; Stavik, Benedicte; Tekpli, Xavier; Garred, Øystein; Borgen, Elin; Kristensen, Vessela N.; Sahlberg, Kristine Kleivi; Sandset, Per Morten & Iversen, Nina (2020). Coagulation factor V is a marker of tumor-infiltrating immune cells in breast cancer. Oncoimmunology.  ISSN 2162-4011.  9:e1824644(1), s 1- 12 . doi: 10.1080/2162402X.2020.1824644 Full text in Research Archive.
• Tritschler, Tobias; Sandset, Per Morten; Mathieu, Marie-Eve; Skeith, Leslie; Rodger, Marc; Middeldorp, Saskia; Brighton, Timothy; Kahn, Susan R; Angus, Derek C; Blondon, Marc; Bonten, Marc J.M.; Cattaneo, Marco; Cushman, Mary; Derde, Lennie P G; DeSancho, Maria T; Diehl, Jean-Luc; Goligher, Ewan; Jilma, Bernd; Jüni, Peter; Lawler, Patrick R; Marietta, Marco; Marshall, John C.; McArthur, Colin; Miranda, Carlos Henrique; Mirault, Tristan; Morici, Nuccia; Perepu, Usha; Schörgenhofer, Christian; Sholzberg, Michelle; Spyropoulos, Alex C.; Webb, Steve A.; Zarychanski, Ryan; Zuily, Stéphane & Le Gal, Grégoire (2020). Anticoagulant interventions in hospitalized patients with COVID-19: A scoping review of randomized controlled trials and call for international collaboration. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933. . doi: 10.1111/jth.15094
• Andersen, Elisabeth; Dugarte, Maria Eugenia Chollet; Baroni, Marcello; Pinotti, Mirko; Bernardi, Francesco; Skarpen, Ellen; Sandset, Per Morten & Skretting, Grethe (2019). The effect of the chemical chaperone 4-phenylbutyrate on secretion and activity of the p.Q160R missense variant of coagulation factor FVII. Cell & Bioscience.  ISSN 2045-3701.  9:69, s 1- 10 . doi: 10.1186/s13578-019-0333-8 Full text in Research Archive.
• Beitland, Sigrid; Wimmer, Rolf Henning; Lorentsen, Torleif; Jacobsen, Dag; Drægni, Tomas; Brunborg, Cathrine; Kløw, Nils-Einar; Sandset, Per Morten & Sunde, Kjetil (2019). Venous thromboembolism in the critically ill: A prospective observational study of occurrence, risk factors and outcome. Acta Anaesthesiologica Scandinavica.  ISSN 0001-5172.  63(5), s 630- 638 . doi: 10.1111/aas.13316 Full text in Research Archive.
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Wik, Hilde Skuterud; Jacobsen, Anne Flem; Mollnes, Tom Eirik; Kanse, Sandip & Sandset, Per Morten (2019). Elevated complement C3 and C4 levels are associated with postnatal pregnancy-related venous thrombosis. Thrombosis and Haemostasis.  ISSN 0340-6245.  119(9), s 1481- 1488 . doi: 10.1055/s-0039-1692426 Full text in Research Archive.
• Eilertsen, Anette Løken; Dahm, Anders Erik A; Høibraaten, Else; Lofthus, Cathrine Marie; Mowinckel, Marie-Christine & Sandset, Per Morten (2019). Relationship between sex hormone binding globulin and blood coagulation in women on postmenopausal hormone treatment. Blood Coagulation and Fibrinolysis.  ISSN 0957-5235.  30(1), s 17- 23 . doi: 10.1097/MBC.0000000000000784
• Engeseth, Marit; Enden, Tone Rønnaug; Andersen, Marit Helen; Sandset, Per Morten & Wik, Hilde Skuterud (2019). Does the Villalta scale capture the essence of postthrombotic syndrome? A qualitative study of patient experience and expert opinion. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  s 1- 8 . doi: 10.1111/jth.14557 Full text in Research Archive.
• Engeseth, Marit; Enden, Tone Rønnaug; Sandset, Per Morten & Wik, Hilde Skuterud (2019). Limitations of the Villalta scale in diagnosing post-thrombotic syndrome. Thrombosis Research.  ISSN 0049-3848.  184, s 62- 66 . doi: 10.1016/j.thromres.2019.10.018 Full text in Research Archive.
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Hellum, Marit Synnøve; Sandset, Per Morten; Bussel, James B.; Tran, Hoa Thi Tuyet & Henriksson, Carola (2019). Increased microvesicle-associated thrombin generation in patients with immune thrombocytopenia after initiation of thrombopoietin receptor agonists. Platelets.  ISSN 0953-7104. . doi: 10.1080/09537104.2019.1639655
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Jonassen, Christine Monceyron; Skov, Vibe; Holst, René; Mowinckel, Marie-Christine; Hasselbalch, Hans Carl; Kruse, Torben A.; Thomassen, Mads; Liebman, Howard; Bussel, James B. & Sandset, Per Morten (2019). Effect of thrombopoietin receptor agonists on markers of coagulation and P-selectin in patients with immune thrombocytopenia. Platelets.  ISSN 0953-7104.  30(2), s 206- 212 . doi: 10.1080/09537104.2017.1394451
• Garabet, Lamya Samir Noori; Ghanima, Waleed Khalid; Rangberg, Anbjørg; Teruel-Montoya, Raul; Martinez, Constantino; Lozano, Maria Luisa; Nystrand, Camilla Furlund; Bussel, James; Sandset, Per Morten & Jonassen, Christine M. (2019). Circulating microRNAs in patients with immune thrombocytopenia before and after treatment wirh thrombopoietin-receptor agonists. Platelets.  ISSN 0953-7104.  s 1- 8 . doi: 10.1080/09537104.2019.1585527 Full text in Research Archive.
• Garabet, Lamya Samir Noori; Henriksson, Carola; Lozano, Maria Luisa; Ghanima, Waleed Khalid; Bussel, James; Brodin, Ellen Elisabeth; Fernández-Pérez, Maria Piedad; Martinez, Constantino; Gónzález-Conejero, Rocío; Mowinckel, Marie-Christine & Sandset, Per Morten (2019). Markers of endothelial cell activation and neutrophil extracellular traps are elevated in immune thrombocytopenia but are not enhanced by thrombopoietin reseptor agonists. Thrombosis Research.  ISSN 0049-3848.  185, s 119- 124 . doi: 10.1016/j.thromres.2019.11.031 Full text in Research Archive.
• Godolphin, Peter J.; Bath, Philip M.; Algra, Ale; Berge, Eivind; Brown, Christopher Martin; Chalmers, John; Duley, Lelia; Eliashiw, Misha; Gregson, John; Greving, Jacoba P.; Hankey, Graeme J.; Hosomi, Naohisa; Johnston, S. Claiborne; Patsko, Emily; Ranta, Annamarei; Sandset, Per Morten; Serena, Joaquín; Weimar, Christian & Montgomery, Alan A. (2019). Outcome assessment by central adjudicators versus site investigators in stroke trials: A systematic review and meta-analysis. Stroke.  ISSN 0039-2499.  50(8), s 2187- 2196 . doi: 10.1161/STROKEAHA.119.025019 Full text in Research Archive. Show summary

  Background and Purpose— In randomized stroke trials, central adjudication of a trial’s primary outcome is regularly implemented. However, recent evidence questions the importance of central adjudication in randomized trials. The aim of this review was to compare outcomes assessed by central adjudicators with outcomes assessed by site investigators. Methods— We included randomized stroke trials where the primary outcome had undergone an assessment by site investigators and central adjudicators. We searched MEDLINE, EMBASE, CENTRAL (Cochrane Central Register of Controlled Trials), Web of Science, PsycINFO, and Google Scholar for eligible studies. We extracted information about the adjudication process as well as the treatment effect for the primary outcome, assessed both by central adjudicators and by site investigators. We calculated the ratio of these treatment effects so that a ratio of these treatment effects >1 indicated that central adjudication resulted in a more beneficial treatment effect than assessment by the site investigator. A random-effects meta-analysis model was fitted to estimate a pooled effect. Results— Fifteen trials, comprising 69 560 participants, were included. The primary outcomes included were stroke (8/15, 53%), a composite event including stroke (6/15, 40%) and functional outcome after stroke measured on the modified Rankin Scale (1/15, 7%). The majority of site investigators were blind to treatment allocation (9/15, 60%). On average, there was no difference in treatment effect estimates based on data from central adjudicators and site investigators (pooled ratio of these treatment effects=1.02; 95% CI, [0.95–1.09]). Conclusions— We found no evidence that central adjudication of the primary outcome in stroke trials had any impact on trial conclusions. This suggests that potential advantages of central adjudication may not outweigh cost and time disadvantages in stroke studies if the primary purpose of adjudication is to ensure validity of trial findings.

• Gregersen, Ida; Høibraaten, Else; Holven, Kirsten Bjørklund; Løvdahl, Lene; Ueland, Thor; Mowinckel, Marie-Christine; Dahl, Tuva Børresdatter; Aukrust, Pål; Halvorsen, Bente & Sandset, Per Morten (2019). Effect of hormone replacement therapy on atherogenic lipid profile in postmenopausal women. Thrombosis Research.  ISSN 0049-3848.  184, s 1- 7 . doi: 10.1016/j.thromres.2019.10.005 Full text in Research Archive.
• Skretting, Grethe; Andersen, Elisabeth; Myklebust, Christiane Filion; Sandset, Per Morten; Tinholt, Mari; Iversen, Nina & Stavik, Benedicte (2019). Transcription factor FOXP3: A repressor of the TFPI gene?. Journal of Cellular Biochemistry.  ISSN 0730-2312.  s 1- 13 . doi: 10.1002/jcb.28563
• Amundsen, Erik Koldberg; Skadberg, Øyvind; Ghanima, Waleed Khalid; Frønæs, Synne Grønvold; Dahm, Anders Erik A; Tøsdal, Margunn Bye; Sandset, Per Morten; Kristoffersen, Ann Helen & Henriksson, Carola (2018). D-Dimer: Aldersjusterte beslutningsgrenser ved diagnostikk av venøs tromboembolisme?. Klinisk Biokemi i Norden.  ISSN 1101-2013.  30(1), s 26- 36
• Andersen, Elisabeth; Dugarte, Maria Eugenia Chollet; Myklebust, Christiane Filion; Pinotti, Mirko; Bernardi, Francesco; Chuansumrit, Ampaiwan; Skarpen, Ellen; Sandset, Per Morten & Skretting, Grethe (2018). Activation of Endoplasmic Reticulum Stress and Unfolded Protein Response in Congenital Factor VII Deficiency. Thrombosis and Haemostasis.  ISSN 0340-6245.  118(4), s 664- 675 . doi: 10.1055/s-0038-1637690
• Dugarte, Maria Eugenia Chollet; Andersen, Elisabeth; Skarpen, Ellen; Myklebust, Christiane Filion; Koehler, Christian; Morth, Jens Preben; Chuansumrit, Ampaiwan; Pinotti, Mirko; Bernardi, Francesco; Thiede, Bernd; Sandset, Per Morten & Skretting, Grethe (2018). Factor VII deficiency: Unveiling the cellular and molecular mechanisms underlying Three model alterations of the enzyme catalytic domain. Biochimica et Biophysica Acta - Molecular Basis of Disease.  ISSN 0925-4439.  1864(3), s 660- 667 . doi: 10.1016/j.bbadis.2017.12.016
• Gravensteen, Ida Kathrine; Jacobsen, Eva-Marie; Sandset, Per Morten; Helgadóttir, Linda Björk; Rådestad, Ingela; Sandvik, Leiv & Ekeberg, Øivind (2018). Anxiety, depression and relationship satisfaction in the pregnancy following stillbirth and after the birth of a live-born baby: A prospective study. BMC Pregnancy and Childbirth.  ISSN 1471-2393.  18(41) . doi: 10.1186/s12884-018-1666-8 Full text in Research Archive.
• Gravensteen, Ida Kathrine; Jacobsen, Eva-Marie; Sandset, Per Morten; Helgadóttir, Linda Björk; Rådestad, Ingela; Sandvik, Leiv & Ekeberg, Øivind (2018). Healthcare utilisation, induced labour and caesarean section in the pregnancy after stillbirth: a prospective study. BJOG: An International Journal of Obstetrics and Gynaecology.  ISSN 1470-0328.  125(2), s 202- 210 . doi: 10.1111/1471-0528.14750 Full text in Research Archive.
• Kostovski, Emil; Frigato, E; Savikj, Mladen; Dahm, Anders Erik A; Sandset, Per Morten; Mowinckel, Marie-Christine; Skretting, Grethe; Østerud, Bjarne; Bertolucci, C & Iversen, Per Ole (2018). Normalization of disrupted clock gene expression in males with tetraplegia: a crossover randomized placebo-controlled trial of melatonin supplementation. Spinal Cord.  ISSN 1362-4393.  s 1- 8 . doi: 10.1038/s41393-018-0176-x Full text in Research Archive.
• Olsson, Maja; Stanne, Tara M.; Pedersén, Annie; Lorentzen, Erik; Kara, Emrah; Martinez-Palaciàn, Adoraciòn; Rønnow Sand, Niels Peter; Jacobsen, Anne Flem; Sandset, Per Morten; Sidelmann, Johannes Jakobsen; Engström, Gunnar; Melander, Olle; Kanse, Sandip & Jern, Christina (2018). Genome-wide analysis of genetic determinants of circulating factor VII-activating protease (FSAP) activity.. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  16(10), s 2024- 2034 . doi: 10.1111/jth.14258 Full text in Research Archive.
• Rodger, Marc; Langlois, Nicole; Middeldorp, Saskia; Kahn, Susan; Sandset, Per Morten; Brighton, Timothy; Huisman, Menno V.; Meyer, Guy; Konstantinides, Stavros; Ageno, Walter; Morange, Pierre-Emmanuel; Garcia, David A.; Kreuziger, Lisa Baumann; Young, Laura; Key, Nigel; Monreal, Manuel & Jiménez, David O. (2018). Initial strides for invent-VTE: Towards global collaboration to accelerate clinical research in venous thromboembolism. Thrombosis Research.  ISSN 0049-3848.  163, s 128- 131 . doi: 10.1016/j.thromres.2018.01.050
• Sacco, Simona; Merki-Feld, Gabriele S.; Ægidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne; Gantenbein, Andreas R.; Kurth, Tobias; Lampl, Christian; Lidegaard, Øjvind; MacGregor, Elizabeth Anne; van den Brink, Antoinette Maassen; Mitsikostas, Dimos-Dimitrios; Nappi, Rossella Elena; Ntaios, George; Paemeleire, Koen; Sandset, Per Morten; Terwindt, Gisela Marie; Vetvik, Kjersti & Martelletti, Paolo (2018). Effect of exogenous estrogens and progestogens on the course of migraine during reproductive age: A consensus statement by the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESCRH). The Journal of Headache and Pain.  ISSN 1129-2369.  19(76) . doi: 10.1186/s10194-018-0896-5 Full text in Research Archive.
• Schultz, Nina Haagenrud; Holme, Pål Andre; Bjørnsen, Stine; Henriksson, Carola; Sandset, Per Morten & Jacobsen, Eva-Marie (2018). The impact of rivaroxaban on primary hemostasis in patients with venous thrombosis. Platelets.  ISSN 0953-7104. . doi: 10.1080/09537104.2018.1557618
• Shapiro, Amy D.; Nakar, Charles; Parker, Joseph M.; Albert, Gary R.; Moran, John E.; Thibaudeau, Karen; Thukral, Neelam; Hardesty, Brandon M.; Laurin, Pierre & Sandset, Per Morten (2018). Plasminogen replacement therapy for the treatment of children and adults with congenital plasminogen deficiency. Blood.  ISSN 0006-4971.  131(12), s 1301- 1310 . doi: 10.1182/blood-2017-09-806729
• Tavoly, Mazdak; Wik, Hilde Skuterud; Sirnes, Per-Anton; Jelsness-Jørgensen, Lars-Petter; Ghanima, Josef P.; Klok, Frederikus A.; Sandset, Per Morten & Ghanima, Waleed Khalid (2018). The impact of post-pulmonary embolism syndrome and its possible determinants. Thrombosis Research.  ISSN 0049-3848.  171, s 84- 91 . doi: 10.1016/j.thromres.2018.09.048
• Tikkinen, Kari A.O.; Craigie, Samantha; Agarwal, Arnav; Violette, Philippe D.; Novara, Giacomo; Cartwright, Rufus; Naspro, Richard; Siemieniuk, Reed A.C.; Ali, Bassel; Eryuzlu, Leyla; Geraci, Johanna; Winkup, Judi; Yoo, Daniel; Gould, Michael K.; Sandset, Per Morten & Guyatt, Gordon H. (2018). Procedure-specific risks of thrombosis and bleeding in urological cancer surgery: systematic review and meta-analysis. European Urology.  ISSN 0302-2838.  73(2), s 242- 251 . doi: 10.1016/j.eururo.2017.03.008 Full text in Research Archive.
• Utne, Kristin Kornelia; Dahm, Anders Erik A; Wik, Hilde Skuterud; Jelsness-Jørgensen, Lars-Petter; Sandset, Per Morten & Ghanima, Waleed Khalid (2018). Rivaroxaban versus warfarin for the prevention of post-thrombotic syndrome. Thrombosis Research.  ISSN 0049-3848.  163, s 6- 11 . doi: 10.1016/j.thromres.2018.01.013
• Wik, Hilde Skuterud; Enden, Tone Rønnaug; Ghanima, Waleed Khalid; Engeseth, Marit; Kahn, Susan R. & Sandset, Per Morten (2018). Diagnostic scales for the post-thrombotic syndrome. Thrombosis Research.  ISSN 0049-3848.  164, s 110- 115 . doi: 10.1016/j.thromres.2017.10.022
• Andresen, Marianne Seierstad; Ali, Huda Omar; Myklebust, Christiane Filion; Sandset, Per Morten; Stavik, Benedicte; Iversen, Nina & Skretting, Grethe (2017). Estrogen induced expression of tissue factor pathway inhibitor-2 in MCF7 cells involves lysine-specific demethylase 1. Molecular and Cellular Endocrinology.  ISSN 0303-7207.  443, s 80- 88 . doi: 10.1016/j.mce.2017.01.016
• Andresen, Marianne Seierstad; Iversen, Nina; Tinholt, Mari; Myklebust, Christiane Filion; Stavik, Benedicte; Sandset, Per Morten & Skretting, Grethe (2017). Analysis of estrogen mediated expression of TFPI-2 by miRNAs in MCF-7 cells. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  1, s 408- 409
• Cui, Xue-Yan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Sahlberg, Kristine Kleivi; Kanse, Sandip; Iversen, Nina & Sandset, Per Morten (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in the breast cancer cell line MCF-7. Thrombosis Research.  ISSN 0049-3848.  157, s 111- 116 . doi: 10.1016/j.thromres.2017.07.013
• Cui, Xueyan; Skretting, Grethe; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip; Iversen, Nina & Sandset, Per Morten (2017). A novel hypoxia response element regulates oxygen-related repression of tissue factor pathway inhibitor in breast cancer. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  1, s 395- 395
• Espada Serrano, Sandra; Stavik, Benedicte; Holm, Sverre; Sagen, Ellen Lund; Bjerkeli, Vigdis; Skjelland, Mona; Dahl, Tuva Børresdatter; Espevik, Terje; Kanse, Sandip; Sandset, Per Morten; Skretting, Grethe & Halvorsen, Bente (2017). Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages. Biochemical and Biophysical Research Communications - BBRC.  ISSN 0006-291X.  491(2), s 442- 448 . doi: 10.1016/j.bbrc.2017.07.070 Show summary

  Endoplasmic reticulum (ER) stress has been shown to play a key role during the initiation and clinical progression of the cardiovascular diseases, such as atherosclerosis. We have recently shown that expression of tissue factor pathway inhibitor (TFPI) in human monocyte-derived macrophages (MDMs) was induced by cholesterol crystals (CC). In the present study we aimed to determine the role of TFPI under ER stress conditions using human MDMs. qRT-PCR and immunohistochemistry analysis were performed to determine the presence of the ER stress marker CCAAT/enhancer binding protein homologous protein (CHOP) and TFPI in human carotid plaque material and also in human MDMs polarized into pro-inflammatory M1 or anti-inflammatory M2 populations. CHOP mRNA levels were upregulated in the plaques compared to healthy vessels, and CHOP protein was localized in the same area as TFPI in the plaques. Both CHOP and TFPI mRNA levels were upregulated after CC treatment, especially in the M2 phenotype, and the ER stress inhibitor 4-phenylbutyric acid (PBA) reversed this effect. Furthermore, CC treatment increased the levels of the pro-inflammatory cytokines TNF-α, IL-6, and IL-8, which for TNF-α and IL-8 was inhibited by PBA, and reduced the levels of the anti-inflammatory cytokine IL-10 in M2-polarized macrophages. Knockdown of TFPI prior to CC treatment exacerbated TNF-α and IL-6 levels, but reduced IL-8 and IL-10 levels. Our results show that CC induce TFPI and cytokine expression in M2-polarized macrophages through activation of the ER stress pathway and that TFPI has a protective effect against TNF-α and IL-6 mediated inflammation. These mechanisms may have implications for the pathogenesis of atherosclerosis.

• Krishnan, Kailash; Jusufovic, Mirza; Sandset, Per Morten & Sandset, Else Charlotte (2017). Antiplatelet Therapy in Noncardioembolic Stroke: A Review of Current Evidence. Seminars in neurology.  ISSN 0271-8235.  37(3), s 366- 375 . doi: 10.1055/s-0037-1603469
• Prebensen, Christian; Trøseid, Marius; Ueland, Thor; Dahm, Anders Erik A; Sandset, Per Morten; Aaberge, Ingeborg Sundsvalen; Waalen, Kristian; Dyrhol-Riise, Anne Ma; Tasken, Kjetil & Kvale, Dag (2017). Immune activation and HIV-specific T cell responses are modulated by a cyclooxygenase-2 inhibitor in untreated HIV-infected individuals: An exploratory clinical trial. PLOS ONE.  ISSN 1932-6203.  12(5) . doi: 10.1371/journal.pone.0176527 Full text in Research Archive.
• Sacco, Simona; Merki-Feld, Gabriele S.; Ægidius, Karen Lehrmann; Bitzer, Johannes; Canonico, Marianne; Kurth, Tobias; Lampl, Christian; Lidegaard, Øjvind; MacGregor, E. Anne; MaassenVanDenBrink, Antoinette; Mitsikostas, Dimos-Dimitrios; Nappi, Rossella Elena; Ntaios, George; Sandset, Per Morten & Martelletti, Paolo (2017). Hormonal contraceptives and risk of ischemic stroke in women with migraine: a consensus statement from the European Headache Federation (EHF) and the European Society of Contraception and Reproductive Health (ESC). The Journal of Headache and Pain.  ISSN 1129-2369.  18:108, s 1- 20 . doi: 10.1186/s10194-017-0815-1
• Sagedal, Solbjørg; Sandvik, Leiv; Klingenberg, Olav & Sandset, Per Morten (2017). β-Thromboglobulin may not reflect platelet activation during haemodialysis with the HeprAN membrane. Scandinavian Journal of Clinical and Laboratory Investigation.  ISSN 0036-5513.  77(8), s 679- 684 . doi: 10.1080/00365513.2017.1397288
• Schultz, Nina Haagenrud; Tran, Hoa Thi Tuyet; Bjørnsen, Stine; Henriksson, Carola; Sandset, Per Morten & Holme, Pål Andre (2017). The reversal effect of prothrombin complex concentrate (PCC), activated PCC and recombinant activated factor VII against anticoagulation of Xa inhibitor. Thrombosis Journal.  ISSN 1477-9560.  15(1) . doi: 10.1186/s12959-017-0129-1
• Skuterud Wik, Hilde; Ghanima, Waleed Khalid; Sandset, Per Morten & Kahn, Susan R (2017). Scoring Systems for Postthrombotic Syndrome. Seminars in Thrombosis and Hemostasis.  ISSN 0094-6176.  43(5), s 500- 504 . doi: 10.1055/s-0037-1599142
• Stavik, Benedicte; Espada, Sandra; Holm, Sverre; Bjerkeli, Vigdis; Sandset, Per Morten; Dahl, Tuva Børresdatter; Skjelland, Mona; Espevik, Terje; Iversen, Nina; Skretting, Grethe & Halvorsen, Bente (2017). TFPI in human atherosclerotic plaques. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  1(s1)
• Stavik, Benedicte; Holm, Sverre; Espada Serrano, Sandra; Iversen, Nina; Sporsheim, Bjørnar; Bjerkeli, Vigdis; Dahl, Tuva Børresdatter; Sandset, Per Morten; Skjelland, Mona; Espevik, Terje; Skretting, Grethe & Halvorsen, Bente (2017). Increased expression of TFPI in human carotid stenosis. Thrombosis Research.  ISSN 0049-3848.  155, s 31- 37 . doi: 10.1016/j.thromres.2017.04.024 Show summary

  INTRODUCTION: Tissue factor (TF) pathway inhibitor (TFPI) is the physiological inhibitor of TF induced blood coagulation and two isoforms exists, TFPIα and TFPIβ. In atherosclerotic plaques, TFPI may inhibit TF activity and thrombus formation, which is the main cause of ischemic stroke in carotid artery disease. We aimed to identify the isoforms of TFPI present in human carotid plaques and potential sources of TFPI. MATERIALS AND METHODS: Human atherosclerotic plaques from carotid endarterectomies were used for mRNA and immunohistochemistry analyses. hPBMCs isolated from buffy coats and THP-1 cells were differentiated and polarized into M1 or M2 macrophages, and subsequently cultured with or without cholesterol crystals (CC). mRNA and protein expression were measured with qRT-PCR and ELISA, respectively, and procoagulant activity was assessed using a two-stage chromogenic assay. RESULTS: TFPIα and TFPIβ mRNA levels were significantly increased in carotid plaques, whereas TF levels were unchanged as compared to healthy arteries. Antibodies against total TFPI showed elevated levels compared to antibodies against free TFPIα, both by immunohistochemical and ELISA detection in plaques. The antibody against total TFPI also co-localized with CD68 and the M1 and M2 markers CD80 and CD163, respectively. The TFPI mRNA expression was elevated and the procoagulant activity was decreased in M2 compared to M1 polarized human macrophages. TFPI was present in early foam cell formation and CC treatment increased the TFPI mRNA expression even further in M2 macrophages. CONCLUSIONS: Our data indicate that both isoforms of TFPI are present in advanced plaques and that anti-inflammatory M2 macrophages may be a potential source of TFPI.

• Tikkinen, Kari A. O.; Craigie, Samantha; Agarwal, Arnav; Siemieniuk, Reed A.C.; Cartwright, Rufus; Violette, Philippe D.; Novara, Giacomo; Naspro, Richard; Agbassi, Chika; Ali, Bassel; Imam, Maha; Ismaila, Nofisat; Kam, Denise; Gould, Michael K.; Sandset, Per Morten & Guyatt, Gordon Henry (2017). Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis.. European Urology.  ISSN 0302-2838.  73(2), s 236- 241 . doi: 10.1016/j.eururo.2017.02.025
• Stavik, Benedicte; Espada Serrano, Sandra; Cui, Xue-Yan; Iversen, Nina; Holm, Sverre; Mowinckel, Marie-Christine; Halvorsen, Bente; Skretting, Grethe & Sandset, Per Morten (2016). EPAS1/HIF-2 alpha-mediated downregulation of tissue factor pathway inhibitor leads to a pro-thrombotic potential in endothelial cells. Biochimica et Biophysica Acta - Molecular Basis of Disease.  ISSN 0925-4439.  1862(4), s 670- 678 . doi: 10.1016/j.bbadis.2016.01.017 Show summary

  Neovascularization and hemorrhaging are evident in advanced atherosclerotic plaques due to hypoxic conditions, and mediate the accumulation of metabolic substrates, inflammatory cells, lipids, and other blood born factors inside the plaque. Tissue factor (TF) pathway inhibitor (TFPI) is mainly expressed by endothelial cells and is the endogenous inhibitor of the coagulation activator TF, which together with the downstream product thrombin can drive plaque progression and atherogenesis. We aimed to investigate the effect of hypoxic conditions on endothelial cell expression and activity of TFPI and TF that are important in coagulation initiation. Hypoxia was induced in primary human umbilical vein endothelial cells using chemicals or 1% oxygen tension, and mRNA and protein expressions were measured using qRT-PCR, ELISA, and Western blot analysis. Microscopy of fluorescence-labeled cells was used to visualize cell-associated TFPI. Cell-surface factor Xa (FXa) activity was measured using a two-stage chromogenic substrate method. We found that hypoxia reduced the TFPI mRNA and protein levels and increased the TF mRNA expression in a dose-dependent manner. The effect on TFPI was apparent on all the protein pools of TFPI, i.e., secreted TFPI, cell-surface associated TFPI, and intracellular TFPI, and seemed to be dependent upon hypoxia inducible factor-2α (HIF-2α). An increase in FXa activity was also observed on the endothelial cell surface, reflecting an increase in pro-thrombotic potential of the cells. Our findings indicate that hypoxic conditions may enhance the pro-coagulant activity of endothelial cells, which may promote atherogenesis in addition to clinical events and thus the severity of atherosclerotic disorders.

• Utne, Kristin Kornelia; Tavoly, Mazdak; Skuterud Wik, Hilde; Jelsness-Jørgensen, Lars-Petter; Holst, René; Sandset, Per Morten & Ghanima, Waleed Khalid (2016). Health-related quality of life after deep vein thrombosis. SpringerPlus.  ISSN 2193-1801.  5(1) . doi: 10.1186/s40064-016-2949-z
• Ali, Huda Omar; Arroyo, Ana Belen V.; Gónzález-Conejero, Rocío; Stavik, Benedicte; Iversen, Nina; Sandset, Per Morten; Martínez, Constantino & Skretting, Grethe (2016). The role of microRNA-27a/b and microRNA-494 in estrogen-mediated downregulation of tissue factor pathway inhibitor α. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  14(6), s 1226- 1237 . doi: 10.1111/jth.13321
• Ali, Huda Omar; Stavik, Benedicte; Myklebust, Christiane Filion; Andersen, Elisabeth; Dahm, Anders Erik A; Iversen, Nina; Sandset, Per Morten & Skretting, Grethe (2016). Oestrogens downregulate tissue factor pathway inhibitor through oestrogen response elements in the 5′-flanking region. PLOS ONE.  ISSN 1932-6203.  11(3) . doi: 10.1371/journal.pone.0152114
• Bates, Shannon M.; Alonso-Coello, Pablo; Tikkinen, Kari A.O.; Ebrahim, Shanil; Lopes, Luciane Cruz; McDonald, Sarah D.; Zhou, Qi; Akl, Elie A.; Neumann, Ignacio; Jacobsen, Anne Flem; Zhang, Yuqing; Santamaria, Amparo; Annichino-Bizzacchi, Joyce Maria; Sandset, Per Morten; Bitar, Wael; Eckman, Mark H. & Guyatt, Gordon H. (2016). Women's values and preferences and health state valuations for thromboprophylaxis during pregnancy: A cross-sectional interview study. Thrombosis Research.  ISSN 0049-3848.  140, s 22- 29 . doi: 10.1016/j.thromres.2015.12.015
• Berntsen, Christopher Friis; Kristiansen, Annette; Akl, Elie A; Sandset, Per Morten; Jacobsen, Eva-Marie; Guyatt, Gordon & Vandvik, Per Olav (2016). Compression Stockings for Preventing the Postthrombotic Syndrome in Patients with Deep Vein Thrombosis. American Journal of Medicine.  ISSN 0002-9343.  129(4), s 447.e1- 447.e20 . doi: 10.1016/j.amjmed.2015.11.031 Show summary

  OBJECTIVE: We conducted a systematic review and meta-analysis to address benefits and harms of using elastic compression stockings after lower-extremity deep vein thrombosis. METHODS: We searched 7 electronic databases through January 15, 2015, including randomized controlled trials (RCTs)/quasi-randomized trials reporting on elastic compression stocking efficacy on postthrombotic syndrome incidence, recurrent venous thromboembolism, mortality, and acute pain after deep vein thrombosis. Two reviewers independently screened records, extracted data, assessed risk of bias, and assessed confidence in effect estimates using Grading of Recommendations Assessment, Development, and Evaluation methodology. We applied random-effects meta-analysis models. RESULTS: We included 5 RCTs (n = 1418) reporting on postthrombotic syndrome. The hazard ratio (HR) for postthrombotic syndrome with elastic compression stockings was 0.69 (95% confidence interval [CI], 0.47-1.02). We have very low confidence in this estimate due to heterogeneity and inclusion of unblinded studies at high risk of bias. Excluding high risk of bias studies, a single large RCT at low risk of bias provided moderate-quality evidence of no effect on postthrombotic syndrome (HR 1.00; 95% CI, 0.81-1.24). Moderate-quality evidence including all 5 studies suggests no effect of elastic compression stockings on recurrent venous thromboembolism (relative risk [RR] 0.88; 95% CI, 0.63-1.24) or mortality (RR 1.00; 95% CI, 0.73-1.37, 5 studies). Moderate-quality evidence from one large RCT does not suggest effect on acute pain after deep vein thrombosis. CONCLUSIONS: The highest-quality evidence available suggests no effect of elastic compression stockings on postthrombotic syndrome or pain relief, from a single large RCT. However, results for preventing postthrombotic syndrome differ substantially across studies, and future guideline updates should reflect uncertainty about treatment effects. Elastic compression stockings are unlikely to prevent death or recurrent venous thromboembolism.

• Cui, Xue-Yan; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip; Jin, Yang; Seidl, Sebastian; Sahlberg, Kristine Kleivi; Iversen, Nina; Skretting, Grethe & Sandset, Per Morten (2016). Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  14(2), s 387- 396 . doi: 10.1111/jth.13206
• Garabet, Lamya Samir Noori; Gilboe, Inge-Margrethe; Mowinckel, Marie-Christine; Jacobsen, Anne Flem; Mollnes, Tom Eirik; Sandset, Per Morten & Jacobsen, Eva-Marie (2016). Antiphospholipid antibodies are associated with low levels of complement C3 and C4 in patients with systemic Lupus Erythematosus. Scandinavian Journal of Immunology.  ISSN 0300-9475.  84(2), s 95- 99 . doi: 10.1111/sji.12445
• HAIG, YLVA; Enden, Tone Rønnaug; Grøtta, Ole Jørgen; Kløw, Nils-Einar; Slagsvold, Carl Erik; Ghanima, Waleed Khalid; Sandvik, Leiv; Hafsahl, Geir; Holme, Pål Andre; Holmen, Lars Olav; Johansen, Anne Mette; Sandbæk, Gunnar & Sandset, Per Morten (2016). Post-thrombotic syndrome after catheter-directed thrombolysis for deep vein thrombosis (CaVenT): 5-year follow-up results of an open-label, randomised controlled trial. The Lancet Haematology.  ISSN 2352-3026.  3(2), s e64- e71 . doi: 10.1016/S2352-3026(15)00248-3
• Johnson, Karen C; Aragaki, Aaron; Jackson, Rebecca; Reiner, Alex P; Sandset, Per Morten; Rosing, Jan; Dahm, Anders Erik A; Rosendaal, Frits; Manson, JoAnn E; Martin, Lisa W; Liu, Simin; Kuller, Lewis H; Cushman, Mary & Rossouw, Jacques E (2016). Tissue factor pathway inhibitor, activated protein C resistance, and risk of coronary heart disease due to combined estrogen plus progestin therapy. Arteriosclerosis, Thrombosis and Vascular Biology.  ISSN 1079-5642.  36(2), s 418- 424 . doi: 10.1161/ATVBAHA.115.306905
• Martin, K.; Beyer-Westendorf, J.; Davidson, B.L.; Huisman, M.V.; Sandset, Per Morten & Moll, S. (2016). Use of the direct oral anticoagulants in obese patients: guidance from the SSC of the ISTH. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  14(6), s 1308- 1313 . doi: 10.1111/jth.13323
• Skuterud Wik, Hilde; Jacobsen, Anne Flem; Mowinckel, Marie-Christine & Sandset, Per Morten (2016). The role of inflammation in post-thrombotic syndrome after pregnancy-related deep vein thrombosis: A population-based, cross-sectional study. Thrombosis Research.  ISSN 0049-3848.  138, s 16- 21 . doi: 10.1016/j.thromres.2015.12.014
• Tavoly, Mazdak; Utne, Kristin Kornelia; Jelsness-Jørgensen, Lars-Petter; Skuterud Wik, Hilde; Klok, Frederikus A; Sandset, Per Morten & Ghanima, Waleed Khalid (2016). Health-related quality of life after pulmonary embolism: a cross-sectional study. BMJ Open.  ISSN 2044-6055.  6(11) . doi: 10.1136/bmjopen-2016-013086
• Tinholt, Mari; Sandset, Per Morten & Iversen, Nina (2016). Polymorphisms of the coagulation system and risk of cancer. Thrombosis Research.  ISSN 0049-3848.  140, s S49- S54 . doi: 10.1016/S0049-3848(16)30098-6
• Tinholt, Mari; Sandset, Per Morten; Mowinckel, Marie-Christine; Garred, Øystein; Sahlberg, Kristine Kleivi; Kristensen, Vessela N.; Børresen-Dale, Anne-Lise; Jacobsen, Anne Flem; Skretting, Grethe & Iversen, Nina (2016). Determinants of acquired activated protein C resistance and D-dimer in breast cancer. Thrombosis Research.  ISSN 0049-3848.  145, s 78- 83 . doi: 10.1016/j.thromres.2016.08.003
• Tiscia, Giovanni Luca; Andersen, Elisabeth; Myklebust, Christiane Filion; Grandone, E.; Sandset, Per Morten & Skretting, Grethe (2016). Functional characterization of annexin A5 gene promoter allelic variants. Thrombosis Research.  ISSN 0049-3848.  144, s 93- 99 . doi: 10.1016/j.thromres.2016.06.009
• Utne, Kristin Kornelia; Ghanima, Waleed Khalid; Foyn, Siv Lindholm; Kahn, Susan; Sandset, Per Morten & Skuterud Wik, Hilde (2016). Development and validation of a tool for patient reporting of symptoms and signs of the post-thrombotic syndrome. Thrombosis and Haemostasis.  ISSN 0340-6245.  115(2), s 233- 463 . doi: 10.1160/TH15-04-0318 Show summary

  Post-thrombotic syndrome (PTS) is a long-term complication of deep-vein thrombosis (DVT). The Villalta scale is the recommended tool for diagnosing PTS, but requires a clinician’s assessment in addition to patient self-assessment. In the present study, we validated a self-administered tool for patient reporting of leg symptoms and signs as a mean to assess PTS. We first validated a form for patient self-reported Villalta (PRV1), then developed and validated a visually assisted form (PRV2). The validity of PRV1 and PRV2 was assessed in patients diagnosed with DVT between 2004 and 2012. Median time from DVT to inclusion was 5.1 and 3.5 years for PRV1 (n=162) and PRV2 (n=94), respectively. Patients were requested to complete the PRV form before a scheduled visit. PTS diagnosed by the original Villalta scale during the visit served as the reference method. PRV1 showed only moderate agreement for diagnosing PTS compared with the original Villalta scale (kappa agreement 0.60, 95 % CI 0.48–0.72), whereas PRV2 showed very good agreement (0.82, 95 % CI 0.71–0.94). In the validation of PRV2, PTS was diagnosed in 54 (57 %) patients according to the original Villalta scale and in 60 (64 %) by PRV2. The sensitivity of PRV2 to detect PTS was 98 % and the specificity was 83 %. We conclude that the visually assisted form for PRV is a valid and sensitive tool for diagnosing PTS. Such a tool could be applied in further clinical studies of PTS, making studies less resource demanding by reducing the need for in-person clinic visits.

• Ali, Huda Omar; Arroyo, Ana Belen V.; Conejero, RG; Stavik, Benedicte; Iversen, Nina; Sandset, Per Morten; Martinez, C & Skretting, Grethe (2015). Novel regulation of TFPI expression by oestrogens in breast cancer cells thorugh miroRNAs. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13, s 263- 264
• Ali, Huda Omar; Stavik, Benedicte; Myklebust, Christiane Filion; Andersen, Elisabeth; Iversen, Nina; Sandset, Per Morten & Skretting, Grethe (2015). Oestrogens regulate TFPI expression through oestrogen response elements in TFPI 5’-flanking region. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13, s 307- 307
• Andresen, Marianne Seierstad; Ali, Huda Omar; Iversen, Nina; Stavik, Benedicte; Myklebust, Christiane Filion; Sandset, Per Morten & Skretting, Grethe (2015). Estrogens upregulate TFPI-2 expression in MCF-7 cells probably through demethylation. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13, s 306- 306
• Beitland, Sigrid; Sandven, Irene; Kjærvik, Lill-Kristin Krohn; Sandset, Per Morten; Sunde, Kjetil & Eken, Torsten (2015). Thromboprophylaxis with low molecular weight heparin versus unfractionated heparin in intensive care patients: a systematic review with meta-analysis and trial sequential analysis. Intensive Care Medicine.  ISSN 0342-4642.  41(7), s 1209- 1219 . doi: 10.1007/s00134-015-3840-z
• Chollett, Maria Eugenia; Skarpen, Ellen; Iversen, Nina; Sandset, Per Morten & Skretting, Grethe (2015). The chemical chaperone sodium 4-phenylbutyrate improves the secretion of the protein CA267T mutant in CHO-K1 cells through the GRASP55 pathway. Cell & Bioscience.  ISSN 2045-3701. . doi: 10.1186/s13578-015-0048-4
• Comerota, Anthony J.; Sandset, Per Morten; Konstantinides, Stavros; De Graaf, Rick; Wakefield, Thomas W.; Arnoldussen, Carsten W.K.P.; Lam, Yee Lai; Van Gent, Wijnand B.; De Wolf, Mark A.F.; Catarinella, Fabio S.; Kurstjens, Ralph L.M.; Alshabatat, Ashraf & Wittens, Cees H.A. (2015). Theme 4: Invasive management of (recurrent) VTE and PTS. Thrombosis Research.  ISSN 0049-3848.  136, s S19- S25 . doi: 10.1016/j.thromres.2015.07.037
• Craigie, Samantha; Tsui, Johnson F.; Agarwal, Arnav; Sandset, Per Morten; Guyatt, Gordon H. & Tikkinen, Kari A. O. (2015). Adherence to mechanical thromboprophylaxis after surgery: A systematic review and meta-analysis. Thrombosis Research.  ISSN 0049-3848.  136(4), s 723- 726 . doi: 10.1016/j.thromres.2015.06.023
• Cui, Xueyan; Tinholt, Mari; Stavik, Benedicte; Dahm, Anders Erik A; Kanse, Sandip; Seidl, Sebastian; Sahlberg, Kristine Kleivi; OSBREAC, Oslo Breast Cancer Consortium; Iversen, Nina; Skretting, Grethe & Sandset, Per Morten (2015). Effect of hypoxia on tissue factor pathway inhibitor expression in breast cancer cell lines and tissues. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13, s 303- 303
• Eckman, Mark H.; Alonso-Coello, Pablo; Guyatt, Gordon H.; Ebrahim, Shanil; Tikkinen, Kari A.O.; Lopes, Luciane Cruz; Neumann, Ignacio; McDonald, Sarah D.; Zhang, Yuqing; Zhou, Qi; Akl, Elie A.; Jacobsen, Anne Flem; Santamaria, Amparo; Annichino-Bizzacchi, Joyce Maria; Bitar, Wael; Sandset, Per Morten & Bates, Shannon M. (2015). Women's values and preferences for thromboprophylaxis during pregnancy: A comparison of direct-choice and decision analysis using patient specific utilities. Thrombosis Research.  ISSN 0049-3848.  136(2), s 341- 347 . doi: 10.1016/j.thromres.2015.05.020
• Iversen, Per Ole; Dahm, Anders Erik A; Skretting, Grethe; Mowinckel, Marie-Christine; Haslestad, Annicke Stranda; Østerud, Bjarne; Sandset, Per Morten & Kostovski, Emil (2015). Reduced peak, but no diurnal variation, in thrombin generation upon melatonin supplementation in tetraplegia. A randomised, placebo-controlled study.. Thrombosis and Haemostasis.  ISSN 0340-6245.  114(5), s 964- 968 . doi: 10.1160/TH15-05-0396
• Kostovski, Emil; Dahm, Anders Erik A; Mowinckel, Marie-Christine; Stranda, Annicke; Skretting, Grethe; Østerud, Bjarne; Sandset, Per Morten & Iversen, Per Ole (2015). Circadian rhythms of hemostatic factors in tetraplegia: a double-blind, randomized, placebo-controlled cross-over study of melatonin. Spinal Cord.  ISSN 1362-4393.  53, s 285- 290 . doi: 10.1038/sc.2014.243
• Pitkänen, Hanna; Jouppila, Annukka; Mowinckel, Marie-Christine; Lemponen, Marja; Patiwael, Sanne; Sandset, Per Morten; Lassila, Riita & Brinkman, Herm Jan M (2015). Enhanced thrombin generation and reduced intact protein S in processed solvent detergent plasma. Thrombosis Research.  ISSN 0049-3848.  135(1), s 167- 174 . doi: 10.1016/j.thromres.2014.10.020
• Sandset, Else Charlotte; Jusufovic, Mirza; Sandset, Per Morten; Bath, Philip M.W. & Berge, Eivind (2015). Effects of blood pressure-lowering treatment in different subtypes of acute ischemic stroke. Stroke.  ISSN 0039-2499.  46(3), s 877- 879 . doi: 10.1161/STROKEAHA.114.008512

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• Kakkos, Stavros K.; Gohel, Manjit; Baekgaard, Niels; Bauersachs, Rupert; Bellmunt-Montoya, Sergi; Black, Stephen A; Cate-Hoek, Arina J. ten; Elalamy, Ismail; Enzmann, Florian K; Geroulakos, George; Gottsäter, Anders; Hunt, Beverley J.; Mansilha, Armando; Nicolaides, Andrew N; Sandset, Per Morten & Stansby, Gerard (2020). Editor's Choice – European Society for Vascular Surgery (ESVS) 2021 Clinical Practice Guidelines on the Management of Venous Thrombosis. European Journal of Vascular and Endovascular Surgery.  ISSN 1078-5884.  61(1), s 9- 82 . doi: 10.1016/j.ejvs.2020.09.023
• Andresen, Marianne Seierstad; Stavik, Benedicte; Sletten, Marit; Tinholt, Mari; Sandset, Per Morten; Iversen, Nina & Skretting, Grethe (2019). MicroRNA-494 upregulates TFPI-2 expression in MCF-7 breast cancer cells.
• Chollet, Maria Eugenia; Andersen, Elisabeth; Skarpen, Ellen; Mowinckel, Marie-Christine; Stavik, Benedicte; Sullivan, Gareth & Sandset, Per Morten (2019). FVII: A human pluripotent stem cell derived hepatocyte model with potential therapeutic applications.. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  3
• Cui, Xueyan; Tjønnfjord, Geir Erland; Kanse, Sandip; Iversen, Nina; Dahm, Anders Erik A; Myklebust, Christiane Filion; Sandanger, Øystein; Sun, Ling; Jiang, Zhong Xing; Ho, Mitchell & Sandset, Per Morten (2019). Tissue factor pathway inhibitor enhances transendothelial migration of chronic lymphocytic leukemia cells trhough CXCL12/CXCR7 chemotaxis. Research and Practice in Thrombosis and Haemostasis.  ISSN 2475-0379.  3
• Sandset, Per Morten & Dahm, Anders Erik Astrup (2019). Is venous thromboembolism a problem in patients with cancer in palliative care?. The Lancet Haematology.  ISSN 2352-3026. . doi: 10.1016/S2352-3026(18)30218-7
• Schultz, Nina Haagenrud; Holme, Pål Andre; Henriksson, Carola; Mowinckel, Marie-Christine; Sandset, Per Morten; Bratseth, Vibeke & Jacobsen, Eva-Marie (2019). The influence of rivaroxaban on markers of fibrinolysis and endothelial cell activation/injury in patients with venous thrombosis. Thrombosis Research.  ISSN 0049-3848.  177, s 154- 156 . doi: 10.1016/j.thromres.2019.03.010
• Tinholt, Mari; Stavik, Benedicte; Sletten, Marit; Garred, Øystein; Tekpli, Xavier; Kristensen, Vessela N.; Sahlberg, Kristine Kleivi; Sandset, Per Morten & Iversen, Nina (2019). Coagulation factor V is associated with immune response and tumor lymphocyte recruitment in breast cancer.
• Stavik, Benedicte; Tinholt, Mari; Skjelland, Mona; Espevik, Terje; Sandset, Per Morten; Halvorsen, Bente & Iversen, Nina (2018). Coagulation factors in human atherosclerotic plaques – a potential link to inflammation?.
• Dahm, Anders Erik A; Jacobsen, Eva-Marie; Jacobsen, Anne Flem; Skuterud Wik, Hilde & Sandset, Per Morten (2017). High complement C3 increases the risk for postnatal venous thrombosis..
• Tikkinen, Kari A.O.; Cartwrigth, R; Gould, Michael K.; Naspro, Richard; Novara, Giacomo; Sandset, Per Morten; Violette, Philippe D & Guyatt, Gordon H. (2017). EAU Guidelines on Thromboprophylaxis in Urological Surgery, In N'Dow James (ed.),  European Association of Urology Guidelines 2017.  European Association of Urology.  ISBN 978-90-79754-91-5.  EAU Guidelines on Thromboprophylaxis in Urological Surgery.  s 1 - 18
• Utne, Kristin Kornelia; Wik, Hilde Skuterud; Jelsness-Jørgensen, Lars-Petter; Sandset, Per Morten; Dahm, Anders Erik A; Tavoly, Mazdak & Ghanima, Waleed Khalid (2017). Rivaroxaban Reduces the Rate of Post-Thrombotic Syndrome After DVT - a Cross-Sectional Study Comparing Rivaroxaban to Warfarin.
• Stavik, Benedicte; Espada, Sandra; Holm, Sverre; Bjerkeli, Vigdis; Sandset, Per Morten; Dahl, Tuva Børresdatter; Skjelland, Mona; Espevik, Terje; Iversen, Nina; Skretting, Grethe & Halvorsen, Bente (2016). Cholesterol crystals induce TFPI expression in alternatively activated human monocyte-derived macrophages. Show summary

  Atherosclerotic disease is denoted by low density lipoprotein (LDL) influx and retention in the artery intima, triggering the recruitment of monocytes causing a low grade chronic inflammation. Tissue factor (TF) pathway inhibitor (TFPI) regulates TF induced blood coagulation. Two isoforms exist, TFPIα and TFPIβ. In addition, TFPIα is also found complexed with LDL with unknown function. Moreover, ApoE-/- TFPI-/+ double KO mice display an atherogenic phenotype. We aimed to identify the cells expressing TFPI isoforms in human atherosclerotic plaques and the function of TFPI in these cells.

• Arntzen, Elisabeth & Sandset, Per Morten (2016). E. Arntzen & P.M. Sandset svarer. Tidsskrift for Den norske legeforening.  ISSN 0029-2001.  136(12/13), s 1062- 1062 . doi: 10.4045/tidsskr.16.0520
• Espada Serrano, Sandra; Holm, Sverre; Bjerkeli, Vigdis; Skjelland, Mona; Dahl, Tuva Børresdatter; Iversen, Nina; Espevik, Terje; Sandset, Per Morten; Skretting, Grethe; Halvorsen, Bente & Stavik, Benedicte (2016). ER stress conditions lead to an upregulation of TFPI and is associated with an anti-apoptotic macrophage phenotype. Show summary

  Endoplasmic reticulum (ER) stress is an important event during the initiation and clinical progression of several cardiovascular diseases, including atherosclerosis. In the present study we determined the role of tissue factor pathway inhibitor (TFPI) under ER stress conditions using human monocyte-derived macrophages (PBMC) and human carotid endarterectomies. TFPI was expressed in carotid plaques from patients with internal carotid stenosis, especially the TFPIα isoform. Moreover, TFPI colocalized with the ER stress marker CHOP in the plaques. Cholesterol crystals (CC) were used in human M1 and M2-polarized macrophages in vitro as an inducer of ER stress. CHOP and TFPI mRNA levels were upregulated after CC treatment, especially in the M2 phenotype. The ER stress inhibitor 4-Phenylbutyric acid (PBA) reversed the CC-mediated upregulation of CHOP and TFPI. Furthermore, M2-polarized macrophages incubated with CC had higher levels of Bcl-2:Bax mRNA ratios and Bcl-2 protein expression, and these effects were reversed by TFPI knockdown and PBA treatment. Our results indicate that TFPI could promote survival of the M2-polarized macrophages under ER stress conditions. These findings may have implications for the pathogenesis of atherosclerosis.

• Stavik, Benedicte; Holm, Sverre; Espada, Sandra; Iversen, Nina; Sporsheim, Bjørnar; Bjerkeli, Vigdis; Dahl, Tuva Børresdatter; Sandset, Per Morten; Skjelland, Mona; Espevik, Terje; Skretting, Grethe & Halvorsen, Bente (2016). Unconventional mechanisms of targeting atherosclerosis.
• Dahm, Anders Erik A; Tiscia, Gianluca; Holmgren, Asbjørn; Jacobsen, Anne Flem; Skretting, Grethe; Grandone, E. & Sandset, Per Morten (2015). Genetic variations in the annexin A5 gene and the risk of pregnancy-related venous thrombosis. Journal of Thrombosis and Haemostasis.  ISSN 1538-7933.  13(3), s 409- 413 . doi: 10.1111/jth.12817
• Iversen, Per Ole; Negaard, Helene Francisca Stigter; Østenstad, Bjørn; Sandset, Per Morten & Kolset, Svein Olav (2015). Evidence for long term hypercoagulopathy, but normalization of markers of extracellular matrix turnover, in patients with non-Hodgkin lymphoma. Leukemia and Lymphoma.  ISSN 1042-8194.  56(8), s 2479- 2481 . doi: 10.3109/10428194.2013.803227

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