Cost-effectiveness analysis of pembrolizumab compared to the standard of care chemotherapy and pembrolizumab combination therapy as first line treatment for PD-L1 positive non-small cell lung cancer in the Slovak Republic
Lung cancer is one of the most common cancers in the world (WHO, 2012). The major risk of a getting lung cancer is smoking, and second-hand smoking. Every year, more than 8000 people in Slovakia are killed by tobacco-caused disease (Tobacco atlas, 2019) and lung cancer is on the 4th place among the 10 top death causes (Ministry of Health, 2019). Non-small cell lung cancer (NSCLC) represents the most frequent histological type of lung cancers (Novello, et al., 2016). Prognosis of lung cancer is poor with a low overall survival rate, which can be explained by the lack of screening procedures and therefore diagnosis at an advanced stage of the disease.
“Is the immunotherapy treatment with pembrolizumab cost-effective compared to first-line chemotherapy standard treatment or pembrolizumab combination therapy in adult patients with PD-L1 positive non-small cell lung cancer in the Slovak Republic?”
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