Pragmatic Trial for HIV Pre-Exposure Prophylaxis roll out in Tanzania-PREPTA

While the HIV prevalence in the general adult population in Tanzania has dropped to 4.7%, recent studies carried out by the group behind this proposal found that the prevalence remain high among men who have sex with men (MSM; 22.3%) and female sex workers (FSW; 30%). PrEP holds the potential to make a significant contribution to lowering HIV incidence in these populations, but has not as of yet been made available in Tanzania. Among issues that have delayed PrEP being made available to MSM and FSW, are concerns about acceptability, uptake and adherence among potential clients, as well as high levels of stigmatization and discrimination of these groups in public health facilities. In order to study the potential uptake and impact of PrEP among MSM and FSW, an innovative PrEP implementation model will be developed and tested in this project. It will use an interactive m-Health platform to establish and maintain contact between health providers and clients, as well as a Peer-to-Peer Mentoring (PPM) approach. The project will take a stepwise phased approach. In work package (WP) 1, a mixed method formative assessment will be conducted to assess the understanding of PrEP among MSM and FSW, their willingness to use this medication, and their opinions on the mobile platform and PPM approach. Factors associated with access to mainstream health services will also be assessed. In WP II, the mobile intervention platform will be developed and peers recruited and trained in collaboration with the at risk populations. Finally, WP III will use a pragmatic quasi-experimental design to assess the effectiveness of the proposed intervention by comparing it to a control group elsewhere in Tanzania (Tanga) where PrEP will be introduced without either the m-Health platform nor PPM. This project will be implemented in collaboration between the University of Oslo, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania and the Tanzania National AIDS Control Programme.

Samarbeid

Prosjektbeskrivelse med vedlegg

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TSD

  • Ja

Biobank

  • Nei

Godkjenninger

Intern fremleggelse - Ja1 fil

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REK - Ja 2 filer

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Tidspunkt for anonymisering og sletting av dataene

  • Sletting: juli 2028

Andre godkjenninger1 fil

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Prosjektleder / prosjektansvarlig ved UiO

Elia Mmbaga

Ansvarlig enhet

Avdeling for samfunnsmedisin og global helse

Forskere

  • Elia Mmbaga
  • Kåre Moen
  • Anne-Lise Orvin Middelthon
  • Anne Olaug Olsen
  • Inga Haaland
  • Hanne Lichtwarck
  • Melkizedeck Leshabari (Muhimbili University of Health and Allied Sciences)
  • Germana Henry Leyna (Muhimbili University of Health and Allied Sciences)
  • Neema Makyao (National AIDS Control Programme, Tanzania)
  • Method Kazaura (Muhimbili University of Health and Allied Sciences)
  • Chrisopher Mbotwa (Muhimbili University of Health and Allied Sciences)
  • Wilhellmuss Mauka (Muhimbili University of Health and Allied Sciences)

Prosjekttype

  • Ph.d.-prosjekt
  • Forskerprosjekt

Helsefaglig forskning

  • Ja

Personopplysninger

  • Ja

Tidsperiode

  • Start: august 2019
  • Slutt: juli 2023