Maternel hyperkolesterolemi og risiko hos barn

During pregnancy and lactation, cholesterol-lowering drugs are contraindicated due to potential detrimental effects on the offspring.  We have previously shown in the largest cohort of pregnant FH women reported to date, that they frequently experience very high levels of lipids, in particular LDL cholesterol. This potentially unfavourably “in utero” environment may suggest that offspring born of FH women may carry an increased risk for disease later in life i.e. in adolescence /adulthood  compared to offspring with paternal FH. Very few studies have investigated this relationship, and the results reported are so far inconsistent. We have preliminary findings suggesting that healthy siblings born of mothers with FH have increased levels of certain haemostatic markers potentially indicating a more unfavourably phenotype compared to healthy control children born of non-FH mothers. Whether maternal hypercholesterolemia confers an unfavourably phenotype on offspring (with and without FH) compared to children with paternal FH is therefore at present unknown. 

The overall aim of this project is to examine if hypercholesterolemia during pregnancy is associated with adverse clinical outcomes and increased levels of disease-related risk markers among the offspring.

 

Prosjektbeskrivelse med vedlegg

TSD

  • Ja

Biobank

  • Nei

Godkjenninger

REK - Ja 2 filer

Tidspunkt for anonymisering og sletting av dataene

  • Anonymisering: desember 2024
  • Sletting: januar 2030

Prosjektleder

Kirsten Bjørklund Holven

Ansvarlig enhet

Avdeling for ernæringsvitenskap

Forskere

Prosjekttype

  • Forskerprosjekt

Helsefaglig forskning

  • Ja

Personopplysninger

  • Ikke besvart

Tidsperiode

  • Start: mai 2014
  • Slutt: desember 2024
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