Plasmakonsentrajoner av mikronæringsstoffer hos pasienter med sigdcellesykdom
Background/aim: Sickle cell disease (SCD) is an inherited condition resulting in abnormal hemoglobin and is characterized by anemia, infections, pain and increased mortality. SCD is frequent in Tanzania (annually 11000 new cases). Red blood cells are easily destroyed in SCD and it is believed that SCD patients suffer from folate deficiency, a B-vitamin critical for cell production. Thus, folic acid supplements are recommended to them. However, there is limited evidence to support the widespread use of folic acid. Moreover, SCD patients are at risk of malnutrition, impaired growth and deficiencies of other micronutrients, but their plasma levels are not established. We will therefore assess micronutrient levels in about 2,000 SCD patients in which relevant data have already been collected.
Relevance: Knowledge about actual micronutrient levels in SCD is necessary for adequate planning of micronutrient supplementation among this vulnerable patient group.
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- Anonymisering: september 2019
- Sletting: desember 2025