Sammenheng mellom kost, lipider og inflammasjon hos barn med FH

In Norway, it is estimated that approximately 16,000 subjects suffer from familial hypercholesterolemia (FH), making it one of the most common genetic diseases in Norway.  This leads to increased plasma level of cholesterol and subsequent risk of premature cardiovascular disease. In addition to drug therapy, all FH patients are advised to follow certain lifestyle and dietary recommendations and for children with FH, dietary recommendations are the first-line therapy before cholesterol-lowering medication may be initiated when the children are at the age of 10 to 14 years. However, the effects of dietary recommendation in children with FH are largely unknown, yet this remains the first line of treatment. A diet low in saturated fat, high in fruits and vegetables and the use of plant sterol fortified margarines is recommended. It is a big challenge for the whole family to follow the dietary recommendation for children with FH, because proper dietary treatment is time consuming and expensive, and requires both knowledge and motivation on the part of children and their parents. Large variations in compliance and effects of the diet are often experienced in the outpatient clinic.

We have recently shown that children and young adults with FH have healthier food choices particularly with respect to dietary fat sources compared to non-FH children and that this was apparent in both young children (11-15 years) as well as young adults (18-28 years). This may suggest that dietary awareness initiated early in childhood can lead to an improved long-term dietary quality in children and young adults with FH underling the importance of dietary

The overall objective is to study the association of compliance to dietary recommendations how this influences markers of disease such as lipid profile (total-, LDL and HDL cholesterol, triglycerides, Lp(a), apoA and apoB), inflammatory markers (e.g CRP, fibrinogen, TNFa, IL-10) in children with FH.  




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Prosjektleder / prosjektansvarlig ved UiO

Kirsten Bjørklund Holven

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Helsefaglig forskning

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  • Slutt: desember 2028