NFR 251282 Targeted perturbation of perineuronal nets in specific neuron types to investigate adaptive plasticity after spinal cord injury
In this proposal we address a major issue in the field of mammalian brain
and spinal cord injury: how adaptive plasticity works at the molecular
level and whether it can be manipulated at the molecular level to direct
reorganization of neuronal circuits. This issue is relevant not only for spinal cord injury (SCI), which we focus on here, but for injuries anywhere in the brain. To address this issue, we will use transgenic technology to perturb the synapse-stabilizing perineuronal nets (PNNs) in selected subpopulations of spinal neurons. We will then use combinations of cutting edge anatomical and physiological technologies to assess how such manipulation influences the targeting of post-SCI synaptic remodelling to different neurons and pathways. These experiments will test the role of PNNs in regulating adaptive plasticity in specific neuron subtypes and provide novel avenues for selectively targeting synaptic plasticity to specific neural circuit components. This would open new opportunities for directing the formation of new synaptic connections after an injury, thereby allowing the selective engineering of neural circuits to accomplish desired functional recovery. The project will therefore provide novel insight with relevance both to the basic science of spinal cord plasticity, as well as to the potential harnessing of adaptive plasticity in a future clinical setting.
REK - Ja 1 fil
Disse dokumentene er kun synlige for prosjektleder, enhetens leder og forskningsadministrasjon.
Tidspunkt for anonymisering og sletting av dataene
- Anonymisering: april 2017
- Sletting: juli 2030