NFR 274249 Non-invasive electrical stimulation of the cervical spinal cord to facilitate arm and hand functional re plasticity after spinal cord injury
The aim of the present proposal is to obtain proof of concept that transcutaneous cervical electrical stimulation modulates cervical spinal networks to facilitate arm and hand function recovery in cervical spinal cord injured patients. This aim will be reached by employing rodent and primate animal models to decipher molecular, cellular and physiological mechanisms that drive stimulation-induced neuromodulation and recovery, and by translating this knowledge to human experiments.
This bottom to top approach employing animal models and human testing will determine the degree to which non-invasive neuromodulation of the cervical spinal cord can facilitate functional recovery of the arm and hand through enhanced transmission within the residual brain-to-spinal cord connectome.
The proposal establishes a consortium with a unique combination of methodological approaches to tackle specific objectives. The human and animal experiments will be run in parallel, with results from experiments exploiting the advantages of each animal species feeding directly into clinical testing with humans. To facilitate the comparison and implementation of the results obtained, the proposal includes sharing and transferring expertise and technology between the laboratories. Stimulation protocols will be designed by Newcastle University (UK), protocols for training rodents (rats and mice) to reach and grasp will be implement by the UAB (Spain), and advanced connectome tools will be employed by the University of Oslo (Norway) to identify circuit elements involved in network plasticity, and clinical testing will be performed at Guttman Rehabilitation Hospital (Spain). Students from each laboratory will engage in training at one of the other consortium laboratories to enhance the integration of specific techniques needed to implement the WPs.
- UiO er forskningsansvarlig
Intern fremleggelse - Ja
Godkjent av: Philippe Collas