Gender differences in circulatory and respiratory compensation to severe blood loss

Severe haemorrhage is potentially fatal. During emergency treatment, health workers must estimate degree of blood loss from the patient’s physiological responses, which thus serve as triage and treatment triggers. During evolution, men would suffer severe bleeding from physical trauma while young women would hemorrhage during childbirth. Optimal compensatory strategies could differ between these settings. The prevailing clinical tool for estimating blood loss underlines tachycardia as sign, based on trauma populations with a large male majority. Non-traumatic bleeding may present differently. Gender differences in physiological response to haemorrhage might lead to underestimation of blood loss and delay adequate treatment for female patients.

Using a lower-body negative pressure chamber we will continuously assess cardiac, circulatory and respiratory compensatory mechanisms in healthy women and men subjected to a graded and substantial reduction in circulating blood volume. Uniquely, each person will be studied at low, normal, and high ambient temperature in a climatic-controlled room. This allows comparison of responses to severe hemorrhage in a vasoconstricted, a normal, and a vasodilated state. The former is common in trauma patients in Nordic countries, the latter mimics severe postpartum hemorrhage occurring in a circulation adapted to pregnancy.

Our results will allow for a “recalibration” of clinical tabulations and mindsets, relevant for many patient populations.

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TSD

  • Ja

Biobank

  • Nei

Godkjenninger

NSD - Ja 1 fil

Disse dokumentene er kun synlige for prosjektleder, enhetens leder og forskningsadministrasjon.

REK - Ja 1 fil

Disse dokumentene er kun synlige for prosjektleder, enhetens leder og forskningsadministrasjon.

Tidspunkt for anonymisering og sletting av dataene

  • Anonymisering: januar 2029
  • Sletting: juni 2029

Statens legemiddelverk - Ikke behov

Prosjektleder / prosjektansvarlig ved UiO

Signe Søvik

Ansvarlig enhet

Klinikk for kirurgiske fag

Forskere

Prosjekttype

  • Ph.d.-prosjekt

Helsefaglig forskning

  • Ja

Personopplysninger

  • Ja

Tidsperiode

  • Start: august 2020
  • Slutt: august 2026