FRM-KJM9050 – Bioanalytical Chemistry I: Advanced Separation Methods and Bioanalysis

Schedule, syllabus and examination date

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Course content

FRM-KJM9050 focuses on the most important aspects in all steps of an analytical method to determine biological active compounds (endogeneous compounds, environmental pollution, drugs etc.) in various biological matrices (like serum, urine, cell culture) and environmental samples (surface water)

Learning outcome

The course discusses the following topics:

  • composition of various sample matrices (biological and environmental) together with their analytical limitations
  • most used sample preparation techniques like liquid-liquid and solid phase extraction (both off-line and on-line)
  • advanced liquid chromatography, column technology, stationary phases and miniaturization
  • LC-MS: ionization, analysis, detection and mass spectrum interpretation
  • LC-MS based doping analysis


PhD candidates from the University of Oslo should apply for classes and register for examinations through Studentweb.

If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers’ schools may have specific rules for ranking applicants for courses with limited intake capacity.

PhD candidates who have been admitted to another higher education institution must apply for a position as a visiting student within a given deadline.


Recommended previous knowledge

Analytical chemistry corresponding to FRM2010 - Quality Control of Pharmaceutical ingredients and FRM3030 - Use of Drugs, Part III (for pharmacy students) or KJM2400 - Analytical chemistry I and KJM3400 - Analytical Chemistry II (for chemistry students).

Overlapping courses

  •   10 credits overlap with FRM-KJM5050 – Bioanalytical chemistry I
  •     5 credits overlap with KJM5460/9460  - Analytical chemistry. Separation methods II
  •     5 credits overlap with FRM5310/9310 - Biomedical analysis


There will be 11 days of lectures and colloquia. PhD students need to present and discuss at least two recent scientific publications which will be handed out on the course (mandatory). The presentations have to be approved before you can attend the final exam. There will be no laboratory training.


Final exam counts 100 %. Depending on the number of students, the final exam will either be a 4 hours long written exam or a 45 minutes long oral exam. The presentation has to be approved before you can attend the final exam.

Examination support material

As of 1 August, 2016, the use of own calculators is no longer permitted. Casio FX-991EX calculators are handed out to all exam candidates at the beginning of the exam.

Language of examination

You may submit your response in Norwegian, Swedish, Danish or English. If you would prefer to have the exam text in English, you may apply to the course administrators.

Grading scale

Grades are awarded on a pass/fail scale. Read more about the grading system.

Explanations and appeals

Resit an examination

This course offers both postponed and resit of examination. Read more:

Withdrawal from an examination

It is possible to take the exam up to 3 times. If you withdraw from the exam after the deadline or during the exam, this will be counted as an examination attempt.

Special examination arrangements

Application form, deadline and requirements for special examination arrangements.


The course is subject to continuous evaluation. At regular intervals we also ask students to participate in a more comprehensive evaluation.

Facts about this course




Every spring


Every spring

Teaching language

Norwegian (English on request)