Pensum/læringskrav

1. LECTURE - promoters

Bell, A. C., West, A. G., and Felsenfeld, G: Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. , 2001. Science. Download.

Blackwood, E. M. and Kadonaga, J. T. : Going the distance: a current view of enhancer action., 1998. Science. Download.

Butler JE, Kadonaga JT: The RNA polymerase II core promoter: a key component in the regulation of gene expression., 2002. Genes Dev. Download.

Levine M, Tjian R: Transcription regulation and animal diversity, 2003. Nature. Download.

2. LECTURE - RNA polymerase

Boeger, H., Bushnell, D.A., Davis, R., Griesenbeck, J., Lorch, Y., Strattan, J.S., Westover, K.D. and Kornberg, R.D. : Structural basis of eukaryotic gene transcription. , 2005. FEBS Lett. Download.

Cramer, P.: RNA polymerase II structure: from core to functional complexes. Curr Opin Genet Dev, , 2004. Curr Opin Genet Dev. Download.

Dahmus, M. E. : Reversible phosphorylation of the C-terminal domain of RNA polymerase II. , 1996. Download.

Myer, V. E. and Young, R. A.: RNA polymerase II holoenzymes and subcomplexes. , 1998. J Biol Chem . Download.

Oelgeschlager, T. : Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control. , 2002. J Cell Physiol . Download.

3. LECTURE - GTFs

Orphanides, G., Lagrange, T., and Reinberg, D. : The general transcription factors of RNA polymerase II. , 1996. Genes Dev 10, 2657-83.

Reese JC: Basal transcription factors, 2003. Curr Opin Genet Dev. Download.

Woychik, N. A. and Hampsey, M.: The RNA Polymerase II Machinery. Structure Illuminates Function. , 2002. Cell. Download.

4. LECTURE - Coactivators & Mediator

Chen, B.S. and Hampsey, M.: Transcription activation: unveiling the essential nature of TFIID. , 2002. Curr Biol. Download.

Green, M. R.: TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes., 2000. Trends Biochem Sci.. Download.

Lewis BA, Reinberg D: The mediator coactivator complex: functional and physical roles in transcriptional regulation., 2003. J Cell Sci. Download.

Tansey, W. P. and Herr, W.: TAFs: guilt by association? , 1997. Cell. Download.

Wassarman, D. A. and Sauer, F.: TAF(II)250: a transcription toolbox., 2001. J Cell Sci. Download.

5. + 6. LECTURE - Chromatin

Brown, C. E.; Lechner, T.; Howe, L., and Workman, J. L. : The many HATs of transcription coactivators. , 2000. Trends Biochem Sci.. Download.

Flaus, A. and Owen-Hughes, T.: Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?, 2004. Curr Opin Genet Dev. Download.

Khorasanizadeh S: The nucleosome: from genomic organization to genomic regulation., 2004. Cell. Download.

Narlikar, G. J., Fan, H. Y., and Kingston, R. E. : Cooperation between Complexes that Regulate Chromatin Structure and Transcription., 2002. Cell. Download.

Peterson, C.L.: Chromatin remodeling enzymes: taming the machines., 2002. EMBO Rep. Download.

Peterson, C.L. and Laniel, M.A.: Histones and histone modifications. , 2004. Curr Biol. Download.

Sims RJ, 3rd, Nishioka K, Reinberg D: Histone lysine methylation: a signature for chromatin function., 2003. Trends Genet. Download.

Sudarsanam, P. and Winston, F.: The Swi/Snf family nucleosome-remodeling complexes and transcriptional control., 2000. Trends Genet. Download.

7. LECTURE - Repression

Courey, A. J. and Jia, S.: Transcriptional repression: the long and the short of it. , 2001. Genes Dev. Download.

Richards EJ, Elgin SC: Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects., 2002. Cell. Download.

8. LECTURE - Elongation

Conaway, J. W., Shilatifard, A., Dvir, A., and Conaway, R. C.: Control of elongation by RNA polymerase II. , 2000. Trends Biochem Sci. Download.

Luo, W. and Bentley, D.: A ribonucleolytic rat torpedoes RNA polymerase II, 2004. Cell. Download.

Orphanides, G. and Reinberg, D.: RNA polymerase II elongation through chromatin. , 2000. Nature. Download.

Proudfoot, N. J., Furger, A., and Dye, M. J. : Integrating mRNA processing with transcription. , 2002. Cell. Download.

Sims, R.J., 3rd, Mandal, S.S. and Reinberg, D.: Recent highlights of RNA-polymerase-II-mediated transcription. , 2004. Curr Opin Cell Biol. Download.

9. LECTURE - Ubi-SUMO

Muratani M, Tansey WP: : How the ubiquitin-proteasome system controls transcription. , 2003. Nat Rev Mol Cell Biol. Download.

Seeler JS, Dejean A:: Nuclear and unclear functions of SUMO. , 2003. Nat Rev Mol Cell Biol. Download.

10. LECTURE - Architectural TFs

Werner, M. H. and Burley, S. K.: Architectural transcription factors: proteins that remodel DNA. , 1997. Cell. Download.

Thomas, J. O. and Travers, A. A.: HMG1 and 2, and related 'architectural' DNA-binding proteins. , 2001. Trends Biochem Sci. Download.

Bustin, M. : Chromatin unfolding and activation by HMGN(*) chromosomal proteins. , 2001. Trends Biochem Sci. Download.

11. LECTURE - homeodomains

Kornberg, T. B.: Understanding the homeodomain. , 1993. J Biol Chem 268, 26813-6.

Phillips, K. and Luisi, B.: The virtuoso of versatility: POU proteins that flex to fit., 2000. J Mol Biol. Download.

12. LECTURE - zinc fingers

Laity, J. H., Lee, B. M., and Wright, P. E.: Zinc finger proteins: new insights into structural and functional diversity. , 2001. Curr Opin Struct Biol. Download.

13. LECTURE - bZIP and bHLH

Ellenberger, T. : Getting av grip on DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains. , 1994. Current Opinion in Structural Biology 4, 12-21.

De Cesare, D.; Fimia, G. M., and Sassone-Corsi, P.: Signaling routes to CREM and CREB: plasticity in transcriptional activation. , 1999. Trends Biochem Sci.. Download.

Massari, M. E. and Murre, C.: Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. , 2000. Mol Cell Biol.. Download.

Luscher, B. : Function and regulation of the transcription factors of the Myc/Max/Mad network. , 2001. Gene. Download.

14. LECTURE - NFkB

Perkins, N. D.: The Rel/NF-kappa B family: friend and foe. , 2000. Trends Biochem Sci. Download.

Israel, A.: The IKK complex: an integrator of all signals that activate NF-kappaB? , 2000. Trends Cell Biol.. Download.

Karin M, Cao Y, Greten FR, Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit., 2002. Nat Rev Cancer. Download.

Viatour, P., Merville, M.P., Bours, V. and Chariot, A. : Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. , 2005. Trends Biochem Sci.. Download.

15. LECTURE - Nuclear receptors

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P. and others : The nuclear receptor superfamily: the second decade. , 1995. Cell 83, 835-9.

Mangelsdorf, D. J. and Evans, R. M. : The RXR heterodimers and orphan receptors. , 1995. Cell 83, 841-50.

Xu, L.; Glass, C. K., and Rosenfeld, M. G.: Coactivator and corepressor complexes in nuclear receptor function. , 1999. Curr Opin Genet Dev.. Download.

Rastinejad, F.: Retinoid X receptor and its partners in the nuclear receptor family. , 2001. Curr Opin Struct Biol. Download.

Egea, P. F., Klaholz, B. P., and Moras, D.: Ligand-protein interactions in nuclear receptors of hormones. , 2000. FEBS Lett. Download.

McKenna, N. J. and O'Malley, B. W.: Combinatorial control of gene expression by nuclear receptors and coregulators., 2002. Cell. Download.

Khorasanizadeh, S. and Rastinejad, F. : Nuclear-receptor interactions on DNA-response elements. , 2001. Trends Biochem Sci. Download.

16. LECTURE - STATs and SMADs

Chatterjee-Kishore, M.; van den Akker, F., and Stark, G. R. : Association of STATs with relatives and friends. , 2000. Trends Cell Biol.. Download.

Horvath, C. M.: STAT proteins and transcriptional responses to extracellular signals. , 2000. Trends Biochem Sci. Download.

Levy DE, Darnell JE, Jr.: : Stats: transcriptional control and biological impact. , 2002. Nat Rev Mol Cell Biol. Download.

Padgett RW, Das P, Krishna S: : TGF-beta signaling, Smads, and tumor suppressors. , 1998. Bioessays. Download.

17. LECTURE - Rb and cell cycle

Weinberg, R. A.: The retinoblastoma protein and cell cycle control. , 1995. Cell 81, 323-30.

Brehm, A. and Kouzarides, T. : Retinoblastoma protein meets chromatin. , 1999. Trends Biochem Sci.. Download.

Sherr, C. J.: The Pezcoller lecture: cancer cell cycles revisited. , 2000. Cancer Res. Download.

Trimarchi, J. M. and Lees, J. A.: Sibling rivalry in the E2F family. , 2002. Nat Rev Mol Cell Biol. Download.

Classon M, Harlow E:: The retinoblastoma tumour suppressor in development and cancer., 2002. Nat Rev Cancer. Download.

18. LECTURE - p53

Levine, A. J.: p53, the cellular gatekeeper for growth and division. , 1997. Cell 88, 323-31.

Prives, C.: Signaling to p53: breaking the MDM2-p53 circuit. , 1998. Cell. Download.

Oren, M.: Regulation of the p53 tumor suppressor protein. , 1999. J Biol Chem.. Download.

Slee EA, O'Connor DJ, Lu X:: To die or not to die: how does p53 decide? , 2004. Oncogene. Download.

Baptiste N, Prives C: : p53 in the cytoplasm: a question of overkill? , 2004. Cell. Download.

Publisert 25. okt. 2004 23:23 - Sist endret 2. mai 2005 00:18