MBV9230 – Eukaryotic Transcription Factors - Structures, Function, Regulation

Schedule, syllabus and examination date

Choose semester

Changes in the course due to coronavirus

Autumn 2020 we plan for teaching and examinations to be conducted as described in the course description and on semester pages. However, changes may occur due to the corona situation. You will receive notifications about any changes at the semester page and/or in Canvas.

Spring 2020: Teaching and examinations was digitilized. See changes and common guidelines for exams at the MN faculty spring 2020.

Course content

The course focuses on current understanding of the structure and function of eukaryotic transcription factors. The aim of the first general part is to give the student an understanding of the main components of the eukaryotic transcription apparatus. Topics covered are: promoters, RNA polymerase II, general transcription factors and coactivators, the role of chromatin structure in transcription, elongation control and the mechanisms of gene activation, as well as nuclear organization. In the second part, specific transcription factors are discussed: homeodomain and POU families, bZIP- and HLH-families, zinc-finger families, the NFkB-family, nuclear receptors, the FOX- and Myb-family, STAT family, p53 and Rb to illustrate the connection between oncogenesis and transcription.

Learning outcome

After completing the course you are expected to have knowlegde about and an overview of the research front in subjects such as:

  • understand central aspects of the complex structure and function of the transcription apparatus which regulates the expression of genes in eucaryotic cells.  
  • understand resent research in the field of eukaryotic transcription.
  • Expertise in conveying a subject by giving a presentation for other participants on the course.

Admission to the course

PhD candidates from the University of Oslo should apply for classes and register for examinations through Studentweb.

If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers’ schools may have specific rules for ranking applicants for courses with limited intake capacity.

PhD candidates who have been admitted to another higher education institution must apply for a position as a visiting student within a given deadline.

BIOS3900 – Biochemistry 2BIOS4010 – Methods in Molecular Biology and Biochemistry I, BIOS4020 – Methods in Molecular Biology and Biochemistry II or corresponding knowledge.

Overlapping courses

Teaching

  • Lectures
  • Seminars with a 15 minutes presentations of a scientific article for the other students. As part of the teaching, all PhD candidates will hold an individual presentation of a scientific article for the other participants on the course.

Examination

  • Final written exam, 3 hours, which counts 100 % towards the finale grade. 

This course has mandatory assignments that must be approved before you can sit the finale exam.

An individual presentation of a research article must be approved before the exam.

Optional oral exam depending on the number of participants. 

It will also be counted as one of the three attempts to sit the exam for this course, if you sit the exam for one of the following courses: MBV4230 – Eukaryotic Transcription Factors - Structures, Function, Regulation

Examination support material

No examination support material is allowed.

Grading scale

Grades are awarded on a pass/fail scale. Read more about the grading system.

Resit an examination

This course offers both postponed and resit of examination. Read more:

Special examination arrangements, use of sources, explanations and appeals

See more about examinations at UiO

Last updated from FS (Common Student System) Aug. 12, 2020 12:15:13 PM

Facts about this course

Credits
10
Level
PhD
Teaching
Autumn

The course is last held autumn 2020

Examination
Autumn

Examination is last held autumn 2022

Teaching language
English