Pensum/læringskrav

List of reviews

Use the URL to download pdf file. Download here.

To get started, you may wish to read the review of Hahn from 2004. This can be downloaded by following the link below.

Hahn: Structure and mechanism of the RNA polymerase II transcription machinery, 2004. Download here.

PLEASE NOTE THAT THE REVIEWS BELOW ARE FROM THE COURSE IN 2005, WHICH IS SIMILAR BUT NOT IDENTICAL TO THE LIST ABOVE

2005 2005 2005

1. LECTURE - promoters

Bell, A. C., West, A. G., and Felsenfeld, G: Insulators and boundaries: versatile regulatory elements in the eukaryotic genome. , 2001. Science. Download.

Blackwood, E. M. and Kadonaga, J. T. : Going the distance: a current view of enhancer action., 1998. Science. Download.

Butler JE, Kadonaga JT: The RNA polymerase II core promoter: a key component in the regulation of gene expression., 2002. Genes Dev. Download.

Levine M, Tjian R: Transcription regulation and animal diversity, 2003. Nature. Download.

2. LECTURE - RNA polymerase

Boeger, H., Bushnell, D.A., Davis, R., Griesenbeck, J., Lorch, Y., Strattan, J.S., Westover, K.D. and Kornberg, R.D. : Structural basis of eukaryotic gene transcription. , 2005. FEBS Lett. Download.

Cramer, P.: RNA polymerase II structure: from core to functional complexes. Curr Opin Genet Dev, , 2004. Curr Opin Genet Dev. Download.

Dahmus, M. E. : Reversible phosphorylation of the C-terminal domain of RNA polymerase II. , 1996. Download.

Myer, V. E. and Young, R. A.: RNA polymerase II holoenzymes and subcomplexes. , 1998. J Biol Chem . Download.

Oelgeschlager, T. : Regulation of RNA polymerase II activity by CTD phosphorylation and cell cycle control. , 2002. J Cell Physiol . Download.

3. LECTURE - GTFs

Orphanides, G., Lagrange, T., and Reinberg, D. : The general transcription factors of RNA polymerase II. , 1996. Genes Dev 10, 2657-83.

Reese JC: Basal transcription factors, 2003. Curr Opin Genet Dev. Download.

Woychik, N. A. and Hampsey, M.: The RNA Polymerase II Machinery. Structure Illuminates Function. , 2002. Cell. Download.

4. LECTURE - Coactivators & Mediator

Chen, B.S. and Hampsey, M.: Transcription activation: unveiling the essential nature of TFIID. , 2002. Curr Biol. Download.

Green, M. R.: TBP-associated factors (TAFIIs): multiple, selective transcriptional mediators in common complexes., 2000. Trends Biochem Sci.. Download.

Lewis BA, Reinberg D: The mediator coactivator complex: functional and physical roles in transcriptional regulation., 2003. J Cell Sci. Download.

Tansey, W. P. and Herr, W.: TAFs: guilt by association? , 1997. Cell. Download.

Wassarman, D. A. and Sauer, F.: TAF(II)250: a transcription toolbox., 2001. J Cell Sci. Download.

5. + 6. LECTURE - Chromatin

Brown, C. E.; Lechner, T.; Howe, L., and Workman, J. L. : The many HATs of transcription coactivators. , 2000. Trends Biochem Sci.. Download.

Flaus, A. and Owen-Hughes, T.: Mechanisms for ATP-dependent chromatin remodelling: farewell to the tuna-can octamer?, 2004. Curr Opin Genet Dev. Download.

Khorasanizadeh S: The nucleosome: from genomic organization to genomic regulation., 2004. Cell. Download.

Narlikar, G. J., Fan, H. Y., and Kingston, R. E. : Cooperation between Complexes that Regulate Chromatin Structure and Transcription., 2002. Cell. Download.

Peterson, C.L.: Chromatin remodeling enzymes: taming the machines., 2002. EMBO Rep. Download.

Peterson, C.L. and Laniel, M.A.: Histones and histone modifications. , 2004. Curr Biol. Download.

Sims RJ, 3rd, Nishioka K, Reinberg D: Histone lysine methylation: a signature for chromatin function., 2003. Trends Genet. Download.

Sudarsanam, P. and Winston, F.: The Swi/Snf family nucleosome-remodeling complexes and transcriptional control., 2000. Trends Genet. Download.

7. LECTURE - Repression

Courey, A. J. and Jia, S.: Transcriptional repression: the long and the short of it. , 2001. Genes Dev. Download.

Richards EJ, Elgin SC: Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects., 2002. Cell. Download.

8. LECTURE - Elongation

Conaway, J. W., Shilatifard, A., Dvir, A., and Conaway, R. C.: Control of elongation by RNA polymerase II. , 2000. Trends Biochem Sci. Download.

Luo, W. and Bentley, D.: A ribonucleolytic rat torpedoes RNA polymerase II, 2004. Cell. Download.

Orphanides, G. and Reinberg, D.: RNA polymerase II elongation through chromatin. , 2000. Nature. Download.

Proudfoot, N. J., Furger, A., and Dye, M. J. : Integrating mRNA processing with transcription. , 2002. Cell. Download.

Sims, R.J., 3rd, Mandal, S.S. and Reinberg, D.: Recent highlights of RNA-polymerase-II-mediated transcription. , 2004. Curr Opin Cell Biol. Download.

9. LECTURE - Ubi-SUMO

Muratani M, Tansey WP: : How the ubiquitin-proteasome system controls transcription. , 2003. Nat Rev Mol Cell Biol. Download.

Seeler JS, Dejean A:: Nuclear and unclear functions of SUMO. , 2003. Nat Rev Mol Cell Biol. Download.

10. LECTURE - Architectural TFs

Werner, M. H. and Burley, S. K.: Architectural transcription factors: proteins that remodel DNA. , 1997. Cell. Download.

Thomas, J. O. and Travers, A. A.: HMG1 and 2, and related 'architectural' DNA-binding proteins. , 2001. Trends Biochem Sci. Download.

Bustin, M. : Chromatin unfolding and activation by HMGN(*) chromosomal proteins. , 2001. Trends Biochem Sci. Download.

11. LECTURE - homeodomains

Kornberg, T. B.: Understanding the homeodomain. , 1993. J Biol Chem 268, 26813-6.

Phillips, K. and Luisi, B.: The virtuoso of versatility: POU proteins that flex to fit., 2000. J Mol Biol. Download.

12. LECTURE - zinc fingers

Laity, J. H., Lee, B. M., and Wright, P. E.: Zinc finger proteins: new insights into structural and functional diversity. , 2001. Curr Opin Struct Biol. Download.

13. LECTURE - bZIP and bHLH

Ellenberger, T. : Getting av grip on DNA recognition: structures of the basic region leucine zipper, and the basic region helix-loop-helix DNA-binding domains. , 1994. Current Opinion in Structural Biology 4, 12-21.

De Cesare, D.; Fimia, G. M., and Sassone-Corsi, P.: Signaling routes to CREM and CREB: plasticity in transcriptional activation. , 1999. Trends Biochem Sci.. Download.

Massari, M. E. and Murre, C.: Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. , 2000. Mol Cell Biol.. Download.

Luscher, B. : Function and regulation of the transcription factors of the Myc/Max/Mad network. , 2001. Gene. Download.

14. LECTURE - NFkB

Perkins, N. D.: The Rel/NF-kappa B family: friend and foe. , 2000. Trends Biochem Sci. Download.

Israel, A.: The IKK complex: an integrator of all signals that activate NF-kappaB? , 2000. Trends Cell Biol.. Download.

Karin M, Cao Y, Greten FR, Li ZW: NF-kappaB in cancer: from innocent bystander to major culprit., 2002. Nat Rev Cancer. Download.

Viatour, P., Merville, M.P., Bours, V. and Chariot, A. : Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation. , 2005. Trends Biochem Sci.. Download.

15. LECTURE - Nuclear receptors

Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P. and others : The nuclear receptor superfamily: the second decade. , 1995. Cell 83, 835-9.

Mangelsdorf, D. J. and Evans, R. M. : The RXR heterodimers and orphan receptors. , 1995. Cell 83, 841-50.

Xu, L.; Glass, C. K., and Rosenfeld, M. G.: Coactivator and corepressor complexes in nuclear receptor function. , 1999. Curr Opin Genet Dev.. Download.

Rastinejad, F.: Retinoid X receptor and its partners in the nuclear receptor family. , 2001. Curr Opin Struct Biol. Download.

Egea, P. F., Klaholz, B. P., and Moras, D.: Ligand-protein interactions in nuclear receptors of hormones. , 2000. FEBS Lett. Download.

McKenna, N. J. and O'Malley, B. W.: Combinatorial control of gene expression by nuclear receptors and coregulators., 2002. Cell. Download.

Khorasanizadeh, S. and Rastinejad, F. : Nuclear-receptor interactions on DNA-response elements. , 2001. Trends Biochem Sci. Download.

16. LECTURE - STATs and SMADs

Chatterjee-Kishore, M.; van den Akker, F., and Stark, G. R. : Association of STATs with relatives and friends. , 2000. Trends Cell Biol.. Download.

Horvath, C. M.: STAT proteins and transcriptional responses to extracellular signals. , 2000. Trends Biochem Sci. Download.

Levy DE, Darnell JE, Jr.: : Stats: transcriptional control and biological impact. , 2002. Nat Rev Mol Cell Biol. Download.

Padgett RW, Das P, Krishna S: : TGF-beta signaling, Smads, and tumor suppressors. , 1998. Bioessays. Download.

17. LECTURE - Rb and cell cycle

Weinberg, R. A.: The retinoblastoma protein and cell cycle control. , 1995. Cell 81, 323-30.

Brehm, A. and Kouzarides, T. : Retinoblastoma protein meets chromatin. , 1999. Trends Biochem Sci.. Download.

Sherr, C. J.: The Pezcoller lecture: cancer cell cycles revisited. , 2000. Cancer Res. Download.

Trimarchi, J. M. and Lees, J. A.: Sibling rivalry in the E2F family. , 2002. Nat Rev Mol Cell Biol. Download.

Classon M, Harlow E:: The retinoblastoma tumour suppressor in development and cancer., 2002. Nat Rev Cancer. Download.

18. LECTURE - p53

Levine, A. J.: p53, the cellular gatekeeper for growth and division. , 1997. Cell 88, 323-31.

Prives, C.: Signaling to p53: breaking the MDM2-p53 circuit. , 1998. Cell. Download.

Oren, M.: Regulation of the p53 tumor suppressor protein. , 1999. J Biol Chem.. Download.

Slee EA, O'Connor DJ, Lu X:: To die or not to die: how does p53 decide? , 2004. Oncogene. Download.

Baptiste N, Prives C: : p53 in the cytoplasm: a question of overkill? , 2004. Cell. Download.

Publisert 25. okt. 2005 12:29 - Sist endret 11. apr. 2006 18:40