The current treatment offered to patients with ciliopathies is symptomatic therapy. It is therefore highly relevant to study ciliogenesis and identify regulators of this biological process. Many of the genes involved in ciliogenesis that have been studied in detail are structural or trafficking proteins. In this project we will focus on signalling proteins, where we plan to determine the role of a family of phosphatases that have previously mainly been studied in the context of colorectal cancer.
Techniques that will be learned include cell culture, immunofluorescence, confocal microscopy, siRNA transfections and qRT-PCR. Electron microscopy is also a possibility.
Research will be located at the Institute for Cancer Research, Oslo University Hospital at the Radium Hospital. Our research group is part of the newly appointed centre of excellence CanCell, which will commence in January 2018. The research environment is excellent and stimulating for young scientists.