MBV9270 – BIOSTRUCT - Advanced Glycobiology
The course describes aspects of glycobiology - an important research area at UiO. Proteins and lipids are modified with glycans through post-translational modifications and become glycoproteins, proteoglycans, and glycolipids which can participate in specific molecular interactions or transport mechanisms of biological importance. At the same time, glycans at the cell surface are often attack sites for harmful microorganisms, while complex glycans of plant origin stimulate the immune system.
After this course you are able to:
- explain how glycosylation of proteins and lipids occurs in prokaryotic and eukaryotic cells and how the glycan portion influences sorting and transport of glycoproteins in intracellular membrane transport.
- understand how glycan structures are studied by modern analytical techniques and how the glycan structures influence the biological activities of the molecules and their binding to glycan binding proteins (lectins).
- explain how glycans at the cell surface represent an evolutionary development an in many cases function as attack site for detrimental microorganisms.
- understand how glycans and the glycan portion of glycoproteins influence different immunological mechanisms.
- interpret data from mass spectrometry and X-ray crystallography and understand how these are generated.
- understand primary and review articles in the glycobiology field and present the essence of these to fellow students.
- hold a seminar over a given aspect within the field of glycobiology.
PhD candidates from the University of Oslo should apply for classes and register for examinations through Studentweb.
If a course has limited intake capacity, priority will be given to PhD candidates who follow an individual education plan where this particular course is included. Some national researchers’ schools may have specific rules for ranking applicants for courses with limited intake capacity.
PhD candidates who have been admitted to another higher education institution must apply for a position as a visiting student within a given deadline.
Recommended previous knowledge
The course is given as 30 hours lectures and 10 hours colloquia/group work with oral presentations. All teaching sessions are obligatory and constitute the curriculum together with hand-outs.
Information about room and teaching hours is on the semester pages for the course MBV4270 – BIOSTRUCT - Advanced Glycobiology (discontinued)
The course is taught intensivelly full time for two weeks in late spring term.
Presented group work must be approved and is a prerequisite to pass the final exam.
An essay over a given subject which must be approved before the exam.
A final written exam (3 hours) is held one week after the end of the course.
Examination support material
No examination support material is allowed.
Grades are awarded on a pass/fail scale. Read more about the grading system.
Explanations and appeals
Resit an examination
This course offers both postponed and resit of examination. Read more:
Withdrawal from an examination
It is possible to take the exam up to 3 times. If you withdraw from the exam after the deadline or during the exam, this will be counted as an examination attempt.
Special examination arrangements
Application form, deadline and requirements for special examination arrangements.
The course is subject to continuous evaluation. At regular intervals we also ask students to participate in a more comprehensive evaluation.
The course is created by GYCONOR at The Faculty of Mathematics and Natural Sciences with partners from Pharmaceutical Dept., Chemistry Dept. and Dept. of Molecular Biosciences. The course is recommended for master and PhD students in this research field, but others are very welcome.