KJM5962 - Applied radiochemistry and molecular imaging
The course emphasises applied radiochemical methods in biomedical imaging. Every day, radiotracer techniques allow for detailed, quantitative studies of tissue function in living systems using sophisticated imaging methods called PET and SPECT in hospitals. In order toexploit the potential of tracing any molecule and its interaction with bimolecular targets on its way through a living organism, particular design and synthesis requirements are to be met. What happens after a radioactive probe leaves the shielded hot cell? Where do the pictures come from and what do they tell us? How far can the method be pushed and what are we really looking at?
Keywords: Detection, Shielding, Imaging (PET/SPECT), Image Resolution, Physical and Chemical limitations for medical application, Quantitative Imaging.
When you have completed this course:
- you understand the practical consequences of physicochemical characteristics of radionuclides in radiotracer studies
- you have a practical comprehension of the physicochemical parameters when dealing with ionizing radiation
- you have basic knowledge of PET and SPECT radionuclides and radiopharmaceuticals in action
- you understand the scope and limitations of PET/SPECT imaging
- you have a good comprehension of the basic principles of quantitative molecular imaging
Formal prerequisite knowledge
A background in chemistry equivalent to KJM1100 - General chemistry (continued), KJM1110 - Organic chemistry I (continued), KJM1120 - Inorganic Chemistry, KJM1130 - Physical Chemistry I - thermodynamics and kinetics, KJM2600 - Physical chemistry II - quantum chemistry and spectroscopy and KJM3200 - Organic Chemistry II, in addtion to either KJM3900 - Radioactivity and radiochemistry or KJM5901 - Radiochemical methods (discontinued), is recommended. Students with a different background must expect to work extra.
You also need the ability to follow lectures and exercises in English.
5 credits overlap with KJM9962 - Applied radiochemistry and molecular imaging
The course comprises 18 lectures. In the second lecture you will also receive a project assignment where your task is to solve a scientific problem. There will be two 45 minute group sessions where you can suggest an approach and discuss progress with the teacher. Then there will be two mandatory seminar days where you present the solution to your problem in at 10 minutes oral presentation, followed by discussion. The project assignment is mandatory and must be completed before you can attend the exam.
It is the soleresponsibility of participants to obtain and maintain study materials provided in each lecture or exercise.
A project assignment with an oral presentation counts 20 % of final grade. The presentation must be completed before you can attend the final exam.
A 2 hours written exam counts 80 % of the final grade.
Language of examination
The examination text is given in English, and you submit your response in English.
Grades are awarded on a scale from A to F, where A is the best grade and F is a fail. Read more about the grading system.
Explanations and appeals
Resit an examination
Students who can document a valid reason for absence from the regular examination are offered a postponed examination at the beginning of the next semester.
Re-scheduled examinations are not offered to students who withdraw during, or did not pass the original examination.
Withdrawal from an examination
It is possible to take the exam up to 3 times. If you withdraw from the exam after the deadline or during the exam, this will be counted as an examination attempt.
Special examination arrangements
Application form, deadline and requirements for special examination arrangements.
The course is subject to continuous evaluation. At regular intervals we also ask students to participate in a more comprehensive evaluation.