FYS4720 – Cellular radio biology
Schedule, syllabus and examination date
The course opens up with an over-view of the physio-chemical principles of absorption of radiation energy at a molecular and cellular level. Special emphasis is then placed on the effect of radiation on DNA and the principles for repair and misrepair of DNA-damages including the connection with genetic injuries and cancer. Several mathematical models for cell inactivation and its dependency of the dose-rate are included. Central themes are also the variation in radiosensitivity with the cell-cycle stage, radiomodifying factors and the influence of radiation damage on cell-cycle regulation and cell death (apoptosis/necrosis). The last few lectures give an introduction to the radiobiological principles forming the basis for the mathematical modelling of time-dose relations within radiotherapy including dose-fractionation, calculation of iso-effect curves and brachytherapy.
After having completed the course you will:
- be able to describe eukaryotic and prokaryotic cells, and for eukaryotic cells internal and external organization and function, regulation of cell proliferation and growth, some aspects of metabolism and macromolecular synthesis as well as types of DNA damage, chromosomal aberrations and DNA repair
- know the mechanistic relation between cell-cycle progression, DNA-repair and cell survival
- understand and be able to describe energy deposit by different types of ionizing radiation in solid substances as well as in aqueous solutions. This includes the target theory and concepts like LET and RBE
- be able to describe the mechanisms for cell inactivation as based on the so-called cellular suicide experiments with incorporated radionuclides
- understand the tight correlation between cell-cycle regulation and the effect of ionizing radiation in general
- be able to perform calculations and evaluations based on different models for cell survival after irradiation
- understand the role of hypoxia in radiation response and cancer development
- understand dose rate- and fractionation effects and the underlying biological mechanisms
- be able to use the alpha-beta-model as a basis for development of the BED/EQD2-model used for planning of dose-fractionation in radiotherapy
Students who are admitted to study programmes at UiO must each semester register which courses and exams they wish to sign up for in Studentweb.
If you are not already enrolled as a student at UiO, please see our information about admission requirements and procedures.
Recommended previous knowledge
10 credits overlap with FYS9720 – Cellular Radio Biology
Number of lectures: 40
In addition one week is reserved for the laboratory exercise. The students are divided into two groups. The number of hours for laboratory exercise per student (hours by the clock) is approximately 20.
The laboratory exercise is compulsory including a final report. The laboratory report is not given a separate mark, but is presented to the sensor during the final oral exam.
As the teaching involves laboratory and/or field work, you should consider taking out a separate travel and personal risk insurance. Read about your insurance cover as a student.
The laboratory report has to be approved in order to take the final exam.
- Final oral exam
Grades are awarded on a scale from A to F, where A is the best grade and F is a fail. Read more about the grading system.
Explanations and appeals
Resit an examination
This course offers both postponed and resit of examination. Read more:
The course is subject to continuous evaluation. At regular intervals we also ask students to participate in a more comprehensive evaluation.