KJM4350 – Protein Crystallography
Schedule, syllabus and examination date
Changes in the course due to coronavirus
As a general rule, exams at the MN Faculty will during the autumn of 2021 be conducted without physical attendance. For reasons relating to the course content, some courses will have on-campus written examination if the current infection rate makes this possible.
The semester page for your course will be updated with any changes in the form of examination. See also more information about examination at the MN Faculty in 2021.
KJM4350 is a very challenging course, giving a thorough introduction to protein crystallography, the most powerful method to study protein structures and biomolecular complexes. The method will be studied in theory and practice, giving a solid foundation for a Masters or PhD project in the subject. The course shall also enable participants to read and judge modern literature in the field.
After completing the course:
- you have fundamental understanding of protein crystallography
- you know important terms and concepts like symmetry, space groups, crystals and crystallization, diffraction, Bragg´s law, phase problem, Fourier synthesis and Fourier analysis, structure determination by multiple isomorphous replacement (MIR), multiple anomalous dispersion (MAD) and molecular replacement (MR), Patterson function, Patterson maps and electron density maps, refinement and validation.
- you gain practical experience related to protein structure determination by X-ray
- you get insight into complementary methods for macromolecular structure determination, such as electron diffraction and nuclear magnetic resonance (NMR) spectroscopy
- you can carry out relevant database searches
- you can read, understand and judge a crystallographic publication
Admission to the course
Students admitted at UiO must apply for courses in Studentweb. Students enrolled in other Master's Degree Programmes can, on application, be admitted to the course if this is cleared by their own study programme.
Nordic citizens and applicants residing in the Nordic countries may apply to take this course as a single course student.
If you are not already enrolled as a student at UiO, please see our information about admission requirements and procedures for international applicants.
Recommended previous knowledge
Basic knowledge of proteins and proficiency in mathematics is recommended.
- 10 credits overlap with KJM3350 – Protein crystallography (discontinued).
- 10 credits overlap with KJM9350 – Protein Crystallography.
The course comprises of 27 hours of lectures and 30 hours of compulsory theoretical exercises and discussion session, 8 hours of compulsory laboratory practicals, and a compulsory literature task that students are to present orally as well as in writing.
To attend the exam, you must have been present at all compulsory activities, and the laboratory course and literature project have to be approved.
It's allowed to drop two of the following compulsory tasks: Patterson exercise, lab report, or written literature task.
The first lecture is mandatory. If you are unable to join, you have to inform the Expedition Office in advance. If not, you will lose access to the course and to the examination.
- Final oral exam which counts 100% towards the final grade.
To attend the exam, you must have been present at all compulsory activities, and the laboratory course and the literature project have to be approved.
It will also be counted as one of the three attempts to sit the exam for this course, if you sit the exam for one of the following courses: KJM9350 – Protein Crystallography
Examination support material
No examination support material is allowed.
Language of examination
You may submit your response in Norwegian, Swedish, Danish or English.
Grades are awarded on a scale from A to F, where A is the best grade and F is a fail. Read more about the grading system.
Resit an examination
This course offers both postponed and resit of examination. Read more: