Timeplan, pensum og eksamensdato

Velg semester

Kort om emnet

The course opens up with an over-view of the physio-chemical principles of absorption of radiation energy at a molecular and cellular level. Special emphasis is then placed on the effect of radiation on DNA and the principles for repair and misrepair of DNA-damages including the connection with genetic injuries and cancer. Several mathematical models for cell inactivation and its dependency of the dose-rate are included. Central themes are also the variation in radiosensitivity with the cell-cycle stage, radiomodifying factors and the influence of radiation damage on cell-cycle regulation and cell death (apoptosis/necrosis). The last few lectures give an introduction to the radiobiological principles forming the basis for the mathematical modelling of time-dose relations within radiotherapy including dose-fractionation, calculation of iso-effect curves and brachytherapy.

Hva lærer du?

After having completed the course you will:

  • understand and be able to describe energy deposit by different types of ionizing radiation in solid substances as well as in aqueous solutions. This includes the target theory and the use of this theory to calculate the molecular weight of the radiosensitive target based on data from survival measurements.
  • be able to perform calculations and evaluations based on different models for cell survival after irradiation: The molecular model (often denoted the alpha-beta-model) as well as the mathematic model for repair-misrepair.
  • be able to describe the mechanisms for cell inactivation as based on the so-called cellular suicide experiments with incorporated radionuclides.
  • know the mechanistic relation between cell-cycle progression, DNA-repair and cell survival.
  • understand the tight correlation between cell-cycle regulation and the effect of ionizing radiation in general.
  • be able to use the alpha-beta-model as a basis for development of the BED-model used for planning of dose-fractionation in radiotherapy.
  • be able to describe several aspects regarding eukaryotic and prokaryotic cells, their internal and external organization and function, regulation of cell proliferation and growth, a little concerning metabolism and macromolecular synthesis and some more regarding types of DNA damage, chromosomal aberrations and DNA repair.
  • have knowledge of the epidemiologic studies regarding induction of cancer by ionizing radiation (radiation carcinogenesis).

Opptak og adgangsregulering

Ph.d.-kandidater ved UiO søker plass på undervisningen og melder seg til eksamen i Studentweb.

Hvis emnet har begrenset kapasitet, vil ph.d.-kandidater som har emnet i sin utdanningsplan ved UiO bli prioritert. Noen nasjonale forskerskoler kan ha egne regler for rangering av søkere til emner med begrenset kapasitet.

Ph.d.-kandidater som har opptak ved andre utdanningsinstitusjoner må innen angitt frist søke om hospitantplass.

Forkunnskaper

Anbefalte forkunnskaper

Overlappende emner

10 studiepoeng overlapp mot FYS4720 – Cellulær radiobiologi

Undervisning

Number of lectures: 40

In addition one week is reserved for the laboratory exercise. The students are divided into two groups. The number of hours for laboratory exercise per student (hours by the clock) is approximately 20.

The laboratory exercise is compulsory including a final report. The laboratory report is not given a separate mark, but is presented to the sensor during the final oral exam.

Ettersom undervisningen innebærer laboratorie- og/eller feltarbeid, bør du vurdere å tegne en egen reise- og personskadeforsikring. Les om hvordan du er forsikret som student.

Eksamen

The laboratory report has to be passed in order to take the final exam.

  • Final oral exam

Karakterskala

Emnet bruker karakterskala bestått/ikke bestått. Les mer om karakterskalaen.

Begrunnelse og klage

Adgang til ny eller utsatt eksamen

Dette emnet tilbyr både utsatt og ny eksamen. Les mer:

Tilrettelagt eksamen

Søknadskjema, krav og frist for tilrettelagt eksamen.

Evaluering av emnet

Vi gjennomfører fortløpende evaluering av emnet, og med jevne mellomrom ber vi studentene delta i en mer omfattende evaluering.

Fakta om emnet

Studiepoeng

10

Nivå

Ph.d.

Undervisning

Hver høst

If the course is offered, a minimum of four students is required for ordinary lectures to take place. If less than four students participate, an exam will be given, but one should not expect ordinary teaching.

Eksamen

Hver høst

Undervisningsspråk

Norsk (engelsk på forespørsel)