KJM5250 – Organic NMR Spectroscopy

Schedule, syllabus and examination date

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Changes in the course due to coronavirus

Autumn 2020 we plan for teaching and examinations to be conducted as described in the course description and on semester pages. However, changes may occur due to the corona situation. You will receive notifications about any changes at the semester page and/or in Canvas.

See general guidelines for examination at the MN Faculty autumn 2020.

Course content

Lectures include the following topics: Chemical shifts, coupling constants, relaxation (T1 and T2). Practical aspects for optimization of NMR experiments. Tuning and Matching. Shimming. Selection of acquisition and processing parameters. Information transfer via coupling constants and through space (Overhauser effect). One dimensional and two dimensional pulse sequences. The time dimensions t1 and t2. The frequency dimensions F1 and F2. "Window functions". Intepretation of spectra. Rational choice of type of experiment, acquisition- and processing-parameters in relation to chemical problem. Vector and spin population models in explanation of NMR phenomena and the individual experiment. Inverse detected experiments. The laboratory course (one day each week for 10 weeks) includes the following NMR experiments which are performed by two or three students together. Pulse angle optimization, selective 1H - 1H decoupling, T1/T2 relaxation time determination, DEPT, NOEDIF, COSY, TOCSY, XHCORR (HETCOR), COLOC, HMBC or HSQC, HMBC, NOESY and ROESY. A new goal from the spring of 2010 is to enhance the competence of setting up new experiments without having a detailed instruction.

Learning outcome

After completion of the course:

  • You will be able to make a rational choice of type of nmr-experiments for the nuclei; 1H, 13C,19F, 31P and 15N and combinations thereof and can choose and implement acquisition- and processing-parameters in relation to chemical problems.
  • You will master vector and spin population models in explanation of nmr phenomena.
  • You understand the concepts of tuning/matching and master the practical art of shimming.
  • You will understand the concepts of T1- and T2-relaxation and you know how to measure them and how to set up and perform experiments to measure them.
  • You understand the concepts of information transfer through electrons in bonds as well as through space via the Overhauser effect. You will understand and can explain the mechanism of the Overhauser effect.
  • You understand the concepts of one- and two- dimensional pulse sequences as well as the time dimensions t1 and t2 and the frequency dimensions f1 and f2.
  • You understand the concepts of and can apply "window functions" and " linear prediction" in one and two dimensions.
  • You understand the differences between inversely and directly detected experiments and know when to choose either of them.
  • You will master: pulse angle optimization, selective 1H-1H decoupling, DEPT(45, 90, 135), COSY(GP), TOCSY(GP), XHCORR (HETCOR), COLOC, HSQC(EDETGP), HMBCGP, NOESY and ROESY experiments.
  • You are able to interpretate and put together information from a series of nmr experiments in elucidation of chemical structures and problems.

Admission to the course

Students admitted at UiO must apply for courses in Studentweb. Students enrolled in other Master's Degree Programmes can, on application, be admitted to the course if this is cleared by their own study programme.

Nordic citizens and applicants residing in the Nordic countries may apply to take this course as a single course student.

If you are not already enrolled as a student at UiO, please see our information about admission requirements and procedures for international applicants.

KJM3000 – Applied Spectroscopy, as well as practical knowledge in acquisition of one dimensional 1H- and 13C-NMR spectra with Bruker Avance instruments using the NMR program TopSpin 1.3. KJM5280 – NMR Spectroscopy is highly recommended.

Overlapping courses


The course includes 20 hours of lectures and a laboratory course of 50 hours.

The laboratory course must be approved prior to the final examination.

A completed and approved laboratory course is valid for six semesters after the semester it was approved.

It is mandatory to attend the first lecture (including students on the waiting list). If you are unable to attend, you must notify the Department of Chemistry before the start of the lecture, otherwise your course registration will be cancelled and you will lose your place in the course.

Attendance at the laboratory course is mandatory. If you are prevented from meeting, you have to show documentation that you were legally absent (medical note from a doctor or similar)

As the teaching involves laboratory and/or field work, you should consider taking out a separate travel and personal risk insurance. Read about your insurance cover as a student.

Access to teaching

A student who has completed compulsory instruction and coursework and has had these approved, is not entitled to repeat that instruction and coursework. A student who has been admitted to a course, but who has not completed compulsory instruction and coursework or had these approved, is entitled to repeat that instruction and coursework, depending on available capacity.


Final oral examination (1 hour).

The examination includes tests of practical skills in the laboratory as well as oral examination of theoretical knowledge.

Approved laboratory course is a prerequisite for taking the exam.

It will also be counted as one of the three attempts to sit the exam for this course, if you sit the exam for one of the following courses: KJM9250 – Organic NMR Spectroscopy

Examination support material

No examination support material is allowed.

Grading scale

Grades are awarded on a scale from A to F, where A is the best grade and F is a fail. Read more about the grading system.

Resit an examination

This course offers both postponed and resit of examination. Read more:

Special examination arrangements, use of sources, explanations and appeals

See more about examinations at UiO

Last updated from FS (Common Student System) Sep. 29, 2020 8:17:04 PM

Facts about this course


Spring 2020

Every other spring.

The course may be cancelled if there are five or fewer students on this course and KJM9250 combined.

Teaching language
Norwegian (English on request)